Insulin resistance: The possible link between gestational diabetes mellitus and hypertensive disorders of pregnancy

Dimitrios S. Mastrogiannis, Michail Spiliopoulos, Wadia Mulla, Carol J. Homko

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Gestational hypertension, preeclampsia, and diabetes are all associated with increased risks of poor maternal and perinatal outcomes. Pregnant women with gestational diabetes have been shown in population studies to have increased risk of pregnancy-associated hypertension compared with nondiabetic women. Moreover, pregnant patients with hypertension are at increased risk for developing gestational diabetes mellitus. It has been hypothesized that this association could be due, at least in part, to insulin resistance. Although insulin resistance is a physiologic phenomenon in normal pregnancy, in predisposed individuals this could lead to hyperinsulinemia with the development of gestational hypertension, gestational diabetes mellitus, or both.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalCurrent diabetes reports
Volume9
Issue number4
DOIs
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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