Insulin, glucose and triglyceride relationships in obese African subjects

B. I. Joffe, Ronald B Goldberg, H. C. Seftel, L. A. Distiller

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aspects of carbohydrate and lipid metabolism were studied in 50 nondiabetic African subjects living in Johannesburg. 26 Of them were overweight, invariably associated with a high carbohydrate intake. In general, the obese group demonstrated significantly raised serum insulin levels, normal glucose tolerance, normal fasting serum triglycerides, and significantly elevated serum cholesterol concentrations. However, the degree of obesity was not significantly correlated with any of these metabolic variables, notably basal or stimulated insulin levels. This suggests that the obese state, per se, was not the major cause of the hyperinsulinemia, and that other factors influenced individual insulin responses or sensitivity. Inconsistently excessive dietary carbohydrate ingestion and an unusual degree of physical activity may have been important. A striking correlation emerged between fasting serum triglycerides and insulin concentrations (both basal and stimulated); the possibility that this reflects acceleration of hepatic triglyceride synthesis by insulin is discussed. The concept of obesity invariably producing insulin resistance and progressive compensatory hyperinsulinism may not apply in all environmental circumstances.

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume28
Issue number6
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Triglycerides
insulin
triacylglycerols
Insulin
Glucose
glucose
hyperinsulinemia
Hyperinsulinism
Serum
fasting
Fasting
obesity
Obesity
Dietary Carbohydrates
carbohydrate intake
dietary carbohydrate
Carbohydrate Metabolism
glucose tolerance
carbohydrate metabolism
Hypercholesterolemia

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Insulin, glucose and triglyceride relationships in obese African subjects. / Joffe, B. I.; Goldberg, Ronald B; Seftel, H. C.; Distiller, L. A.

In: American Journal of Clinical Nutrition, Vol. 28, No. 6, 01.12.1975, p. 616-620.

Research output: Contribution to journalArticle

Joffe, B. I. ; Goldberg, Ronald B ; Seftel, H. C. ; Distiller, L. A. / Insulin, glucose and triglyceride relationships in obese African subjects. In: American Journal of Clinical Nutrition. 1975 ; Vol. 28, No. 6. pp. 616-620.
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