Insulin feedback action on pancreatic β-cell function

Ingo B. Leibiger, Barbara Leibiger, Per Olof Berggren

Research output: Contribution to journalShort survey

81 Scopus citations

Abstract

Pancreatic β-cell function is essential for the regulation of glucose homeostasis and its impairment leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from neural and humoral components and intraislet cell-cell communication act together to guarantee an appropriate pancreatic β-cell function. Data obtained over the last 5 years in several laboratories have revitalized a controversial concept, namely the autocrine feedback action of secreted insulin on β-cell function. While, historically, insulin was suggested to exert a negative effect on β-cells, recent data provide evidence for a positive role of insulin in transcription, translation, ion flux, insulin secretion and β-cell survival.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalFEBS letters
Volume532
Issue number1-2
DOIs
StatePublished - Dec 4 2002

Keywords

  • Diabetes mellitus
  • Gene expression
  • Insulin
  • Insulin receptor
  • Insulin secretion

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Leibiger, I. B., Leibiger, B., & Berggren, P. O. (2002). Insulin feedback action on pancreatic β-cell function. FEBS letters, 532(1-2), 1-6. https://doi.org/10.1016/S0014-5793(02)03627-X