Insulin degradation in hepatic cirrhosis

Jiroichi Ono, Duane Hutson, Roy S. Dombro, Robert Zeppa, Taketo Katsuki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatic insulinase activity was studied in cirrhosis in an attempt to explain the hyperinsulinemia known to occur in this disease. Liver tissue was obtained during laparotomy in seven patients with cirrhosis of the liver and five patients without liver disease. Insulin degradation was significantly decreased in the cirrhotic liver at each time interval measured (p<0.05). Insulinase inhibitor activity was measured in the plasma of 12 patients with cirrhosis of the liver and six controls. There was no significant difference between the two groups. De creased insulinase activity in cirrhosis may account, in part, for the hyperinsulinemia seen in this disease.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalGastroenterologia Japonica
Volume19
Issue number2
DOIs
StatePublished - Apr 1 1984

Fingerprint

Insulysin
Liver Cirrhosis
Hyperinsulinism
Insulin
Liver
Fibrosis
Laparotomy
Liver Diseases

Keywords

  • cirrhosis
  • insulinase
  • insulinase inhibitor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ono, J., Hutson, D., Dombro, R. S., Zeppa, R., & Katsuki, T. (1984). Insulin degradation in hepatic cirrhosis. Gastroenterologia Japonica, 19(2), 99-103. https://doi.org/10.1007/BF02806930

Insulin degradation in hepatic cirrhosis. / Ono, Jiroichi; Hutson, Duane; Dombro, Roy S.; Zeppa, Robert; Katsuki, Taketo.

In: Gastroenterologia Japonica, Vol. 19, No. 2, 01.04.1984, p. 99-103.

Research output: Contribution to journalArticle

Ono, J, Hutson, D, Dombro, RS, Zeppa, R & Katsuki, T 1984, 'Insulin degradation in hepatic cirrhosis', Gastroenterologia Japonica, vol. 19, no. 2, pp. 99-103. https://doi.org/10.1007/BF02806930
Ono J, Hutson D, Dombro RS, Zeppa R, Katsuki T. Insulin degradation in hepatic cirrhosis. Gastroenterologia Japonica. 1984 Apr 1;19(2):99-103. https://doi.org/10.1007/BF02806930
Ono, Jiroichi ; Hutson, Duane ; Dombro, Roy S. ; Zeppa, Robert ; Katsuki, Taketo. / Insulin degradation in hepatic cirrhosis. In: Gastroenterologia Japonica. 1984 ; Vol. 19, No. 2. pp. 99-103.
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