Insulin degradation in hepatic cirrhosis

Jiroichi Ono, Duane G. Hutson, Roy S. Dombro, Robert Zeppa, Taketo Katsuki

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Hepatic insulinase activity was studied in cirrhosis in an attempt to explain the hyperinsulinemia known to occur in this disease. Liver tissue was obtained during laparotomy in seven patients with cirrhosis of the liver and five patients without liver disease. Insulin degradation was significantly decreased in the cirrhotic liver at each time interval measured (p<0.05). Insulinase inhibitor activity was measured in the plasma of 12 patients with cirrhosis of the liver and six controls. There was no significant difference between the two groups. De creased insulinase activity in cirrhosis may account, in part, for the hyperinsulinemia seen in this disease.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalGastroenterologia Japonica
Issue number2
StatePublished - Apr 1984


  • cirrhosis
  • insulinase
  • insulinase inhibitor

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Insulin degradation in hepatic cirrhosis'. Together they form a unique fingerprint.

Cite this