Insulin: A critical autoantigen and potential therapeutic agent in type 1 diabetes

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Insulin is a polypeptide hormone secreted by pancreatic β-cells and is critical for glucose homeostasis. Abnormalities in insulin secretion result in various forms of diabetes. Type 1A diabetes is an autoimmune form in which insulin has been identified as a critical autoantigen. Recent studies have identified genetic determinants of insulin-specific autoimmune responses and insulin epitopes targeted by autoreactive T lymphocytes. The study of insulin as an autoantigen has also led to discoveries about basic mechanisms of immunological tolerance and autoimmunity. Experimental and clinical evidence suggests that insulin and insulin-derived peptides may delay and perhaps prevent the development of diabetes. Further clinical trials may identify effective treatment modalities for inhibiting diabetogenic autoimmunity and preventing disease development.

Original languageEnglish
Pages (from-to)419-431
Number of pages13
JournalExpert Review of Clinical Immunology
Volume2
Issue number3
DOIs
StatePublished - May 1 2006

Fingerprint

Autoantigens
Type 1 Diabetes Mellitus
Insulin
Autoimmunity
Therapeutics
Pancreatic Polypeptide
Epitopes
Homeostasis
Clinical Trials
T-Lymphocytes
Glucose
Peptides

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Insulin : A critical autoantigen and potential therapeutic agent in type 1 diabetes. / Pugliese, Alberto.

In: Expert Review of Clinical Immunology, Vol. 2, No. 3, 01.05.2006, p. 419-431.

Research output: Contribution to journalArticle

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