Insula response and connectivity during social and non-social attention in children with autism

Paola Odriozola, Lucina Q. Uddin, Charles J. Lynch, John Kochalka, Tianwen Chen, Vinod Menon

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Autism spectrum disorder (ASD) is characterized by reduced attention to salient social stimuli. Here, we use two visual oddball tasks to investigate brain systems engaged during attention to social (face) and non-social (scene) stimuli. We focused on the dorsal and ventral subdivisions of the anterior insula (dAI and vAI, respectively), anatomically distinct regions contributing to a 'salience network' that is known to regulate attention to behaviorally meaningful stimuli. Children with ASD performed comparably to their typically developing (TD) peers, but they engaged the right dAI and vAI differently in response to deviant faces compared with deviant scenes. Multivariate activation patterns in the dAI reliably discriminated between children with ASD and TD children with 85% classification accuracy, and children with ASD activated the vAI more than their TD peers. Children with ASD and their TD peers also differed in dAI connectivity patterns to deviant faces, with stronger within-salience network interactions in the ASD group and stronger cross-network interactions in the TD group. Our findings point to atypical patterns of right anterior insula activation and connectivity in ASD and suggest that multiple functions subserved by the insula, including attention and affective processing of salient social stimuli, are aberrant in children with the disorder.

Original languageEnglish (US)
Pages (from-to)433-444
Number of pages12
JournalSocial cognitive and affective neuroscience
Volume11
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Functional connectivity
  • Multivariate pattern analysis
  • Oddball
  • autism spectrum disorder
  • salience network

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

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