Insights into quantitative diffusion-weighted MRI for musculoskeletal tumor imaging.

Ty Subhawong, Michael A. Jacobs, Laura M. Fayad

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The purposes of this article are to discuss the technical considerations for performing quantitative diffusion-weighted MRI (DWI) with apparent diffusion coefficient (ADC) mapping, examine the role of DWI in whole-body MRI, and review how DWI with ADC mapping can serve as an adjunct to information gleaned from conventional MRI in the radiologic evaluation of musculoskeletal lesions. The primary role of whole-body DWI is in tumor detection; localized DWI is helpful in differentiating malignant bone and soft-tissue lesions. After treatment, an increase in tumor ADC values correlates with response to cytotoxic therapy. The use of DWI in the evaluation of musculoskeletal lesions requires knowledge of potential diagnostic pitfalls that stem from technical challenges and confounding biochemical factors that influence ADC maps but are unrelated to lesion cellularity.

Original languageEnglish
Pages (from-to)560-572
Number of pages13
JournalAJR. American journal of roentgenology
Volume203
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Diffusion Magnetic Resonance Imaging
Neoplasms
Bone and Bones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Insights into quantitative diffusion-weighted MRI for musculoskeletal tumor imaging. / Subhawong, Ty; Jacobs, Michael A.; Fayad, Laura M.

In: AJR. American journal of roentgenology, Vol. 203, No. 3, 01.01.2014, p. 560-572.

Research output: Contribution to journalArticle

@article{b7a773c767ac4ef0a8319c6405e13c35,
title = "Insights into quantitative diffusion-weighted MRI for musculoskeletal tumor imaging.",
abstract = "The purposes of this article are to discuss the technical considerations for performing quantitative diffusion-weighted MRI (DWI) with apparent diffusion coefficient (ADC) mapping, examine the role of DWI in whole-body MRI, and review how DWI with ADC mapping can serve as an adjunct to information gleaned from conventional MRI in the radiologic evaluation of musculoskeletal lesions. The primary role of whole-body DWI is in tumor detection; localized DWI is helpful in differentiating malignant bone and soft-tissue lesions. After treatment, an increase in tumor ADC values correlates with response to cytotoxic therapy. The use of DWI in the evaluation of musculoskeletal lesions requires knowledge of potential diagnostic pitfalls that stem from technical challenges and confounding biochemical factors that influence ADC maps but are unrelated to lesion cellularity.",
author = "Ty Subhawong and Jacobs, {Michael A.} and Fayad, {Laura M.}",
year = "2014",
month = "1",
day = "1",
doi = "10.2214/AJR.13.12165",
language = "English",
volume = "203",
pages = "560--572",
journal = "AJR. American journal of roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "3",

}

TY - JOUR

T1 - Insights into quantitative diffusion-weighted MRI for musculoskeletal tumor imaging.

AU - Subhawong, Ty

AU - Jacobs, Michael A.

AU - Fayad, Laura M.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The purposes of this article are to discuss the technical considerations for performing quantitative diffusion-weighted MRI (DWI) with apparent diffusion coefficient (ADC) mapping, examine the role of DWI in whole-body MRI, and review how DWI with ADC mapping can serve as an adjunct to information gleaned from conventional MRI in the radiologic evaluation of musculoskeletal lesions. The primary role of whole-body DWI is in tumor detection; localized DWI is helpful in differentiating malignant bone and soft-tissue lesions. After treatment, an increase in tumor ADC values correlates with response to cytotoxic therapy. The use of DWI in the evaluation of musculoskeletal lesions requires knowledge of potential diagnostic pitfalls that stem from technical challenges and confounding biochemical factors that influence ADC maps but are unrelated to lesion cellularity.

AB - The purposes of this article are to discuss the technical considerations for performing quantitative diffusion-weighted MRI (DWI) with apparent diffusion coefficient (ADC) mapping, examine the role of DWI in whole-body MRI, and review how DWI with ADC mapping can serve as an adjunct to information gleaned from conventional MRI in the radiologic evaluation of musculoskeletal lesions. The primary role of whole-body DWI is in tumor detection; localized DWI is helpful in differentiating malignant bone and soft-tissue lesions. After treatment, an increase in tumor ADC values correlates with response to cytotoxic therapy. The use of DWI in the evaluation of musculoskeletal lesions requires knowledge of potential diagnostic pitfalls that stem from technical challenges and confounding biochemical factors that influence ADC maps but are unrelated to lesion cellularity.

UR - http://www.scopus.com/inward/record.url?scp=84907882490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907882490&partnerID=8YFLogxK

U2 - 10.2214/AJR.13.12165

DO - 10.2214/AJR.13.12165

M3 - Article

VL - 203

SP - 560

EP - 572

JO - AJR. American journal of roentgenology

JF - AJR. American journal of roentgenology

SN - 0361-803X

IS - 3

ER -