Insights into quantitative diffusion-weighted MRI for musculoskeletal tumor imaging

Ty K. Subhawong, Michael A. Jacobs, Laura M. Fayad

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


The purposes of this article are to discuss the technical considerations for performing quantitative diffusion-weighted MRI (DWI) with apparent diffusion coefficient (ADC) mapping, examine the role of DWI in whole-body MRI, and review how DWI with ADC mapping can serve as an adjunct to information gleaned from conventional MRI in the radiologic evaluation of musculoskeletal lesions. The primary role of whole-body DWI is in tumor detection; localized DWI is helpful in differentiating malignant bone and soft-tissue lesions. After treatment, an increase in tumor ADC values correlates with response to cytotoxic therapy. The use of DWI in the evaluation of musculoskeletal lesions requires knowledge of potential diagnostic pitfalls that stem from technical challenges and confounding biochemical factors that influence ADC maps but are unrelated to lesion cellularity.

Original languageEnglish (US)
Pages (from-to)560-572
Number of pages13
JournalAmerican Journal of Roentgenology
Issue number3
StatePublished - Sep 1 2014


  • Bone tumor
  • Diffusion-weighted imaging
  • MRI
  • Neoplasm
  • Soft-tissue tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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