Insights into myosin regulatory and essential light chains: a focus on their roles in cardiac and skeletal muscle function, development and disease

Yoel H. Sitbon, Sunil Yadav, Katarzyna Kazmierczak, Danuta Szczesna-Cordary

Research output: Contribution to journalArticle

Abstract

The activity of cardiac and skeletal muscles depends upon the ATP-coupled actin–myosin interactions to execute the power stroke and muscle contraction. The goal of this review article is to provide insight into the function of myosin II, the molecular motor of the heart and skeletal muscles, with a special focus on the role of myosin II light chain (MLC) components. Specifically, we focus on the involvement of myosin regulatory (RLC) and essential (ELC) light chains in striated muscle development, isoform appearance and their function in normal and diseased muscle. We review the consequences of isoform switching and knockout of specific MLC isoforms on cardiac and skeletal muscle function in various animal models. Finally, we discuss how dysregulation of specific RLC/ELC isoforms can lead to cardiac and skeletal muscle diseases and summarize the effects of most studied mutations leading to cardiac or skeletal myopathies.

Original languageEnglish (US)
JournalJournal of Muscle Research and Cell Motility
DOIs
StatePublished - Jan 1 2019

Fingerprint

Myosin Light Chains
Muscle Development
Myosin Type II
Muscle
Myocardium
Protein Isoforms
Skeletal Muscle
Striated Muscle
Muscular Diseases
Myosins
Muscle Contraction
Animal Models
Adenosine Triphosphate
Stroke
Light
Muscles
Mutation
Animals

Keywords

  • Development
  • Essential light chain
  • Function
  • Heart
  • Myopathy
  • Myosin
  • Regulatory light chain
  • Skeletal muscle
  • Transgenic mice

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Cell Biology

Cite this

@article{c440d23754544c99beb4b9dd394246d7,
title = "Insights into myosin regulatory and essential light chains: a focus on their roles in cardiac and skeletal muscle function, development and disease",
abstract = "The activity of cardiac and skeletal muscles depends upon the ATP-coupled actin–myosin interactions to execute the power stroke and muscle contraction. The goal of this review article is to provide insight into the function of myosin II, the molecular motor of the heart and skeletal muscles, with a special focus on the role of myosin II light chain (MLC) components. Specifically, we focus on the involvement of myosin regulatory (RLC) and essential (ELC) light chains in striated muscle development, isoform appearance and their function in normal and diseased muscle. We review the consequences of isoform switching and knockout of specific MLC isoforms on cardiac and skeletal muscle function in various animal models. Finally, we discuss how dysregulation of specific RLC/ELC isoforms can lead to cardiac and skeletal muscle diseases and summarize the effects of most studied mutations leading to cardiac or skeletal myopathies.",
keywords = "Development, Essential light chain, Function, Heart, Myopathy, Myosin, Regulatory light chain, Skeletal muscle, Transgenic mice",
author = "Sitbon, {Yoel H.} and Sunil Yadav and Katarzyna Kazmierczak and Danuta Szczesna-Cordary",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s10974-019-09517-x",
language = "English (US)",
journal = "Journal of Muscle Research and Cell Motility",
issn = "0142-4319",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Insights into myosin regulatory and essential light chains

T2 - a focus on their roles in cardiac and skeletal muscle function, development and disease

AU - Sitbon, Yoel H.

AU - Yadav, Sunil

AU - Kazmierczak, Katarzyna

AU - Szczesna-Cordary, Danuta

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The activity of cardiac and skeletal muscles depends upon the ATP-coupled actin–myosin interactions to execute the power stroke and muscle contraction. The goal of this review article is to provide insight into the function of myosin II, the molecular motor of the heart and skeletal muscles, with a special focus on the role of myosin II light chain (MLC) components. Specifically, we focus on the involvement of myosin regulatory (RLC) and essential (ELC) light chains in striated muscle development, isoform appearance and their function in normal and diseased muscle. We review the consequences of isoform switching and knockout of specific MLC isoforms on cardiac and skeletal muscle function in various animal models. Finally, we discuss how dysregulation of specific RLC/ELC isoforms can lead to cardiac and skeletal muscle diseases and summarize the effects of most studied mutations leading to cardiac or skeletal myopathies.

AB - The activity of cardiac and skeletal muscles depends upon the ATP-coupled actin–myosin interactions to execute the power stroke and muscle contraction. The goal of this review article is to provide insight into the function of myosin II, the molecular motor of the heart and skeletal muscles, with a special focus on the role of myosin II light chain (MLC) components. Specifically, we focus on the involvement of myosin regulatory (RLC) and essential (ELC) light chains in striated muscle development, isoform appearance and their function in normal and diseased muscle. We review the consequences of isoform switching and knockout of specific MLC isoforms on cardiac and skeletal muscle function in various animal models. Finally, we discuss how dysregulation of specific RLC/ELC isoforms can lead to cardiac and skeletal muscle diseases and summarize the effects of most studied mutations leading to cardiac or skeletal myopathies.

KW - Development

KW - Essential light chain

KW - Function

KW - Heart

KW - Myopathy

KW - Myosin

KW - Regulatory light chain

KW - Skeletal muscle

KW - Transgenic mice

UR - http://www.scopus.com/inward/record.url?scp=85066260838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066260838&partnerID=8YFLogxK

U2 - 10.1007/s10974-019-09517-x

DO - 10.1007/s10974-019-09517-x

M3 - Article

AN - SCOPUS:85066260838

JO - Journal of Muscle Research and Cell Motility

JF - Journal of Muscle Research and Cell Motility

SN - 0142-4319

ER -