Insights into cardiac iks (Kcnq1/kcne1) channels regulation

Xiaoan Wu, H. Peter Larsson

Research output: Contribution to journalReview articlepeer-review

Abstract

The delayed rectifier potassium IKs channel is an important regulator of the duration of the ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) encoding the IKs channel cause long QT syndrome (LQTS). LQTS is a heart disorder that can lead to severe cardiac arrhythmias and sudden cardiac death. A better understanding of the IKs channel (here called the KCNQ1/KCNE1 channel) properties and activities is of great importance to find the causes of LQTS and thus potentially treat LQTS. The KCNQ1/KCNE1 channel belongs to the superfamily of voltage-gated potassium channels. The KCNQ1/KCNE1 channel consists of both the pore-forming subunit KCNQ1 and the modulatory subunit KCNE1. KCNE1 regulates the function of the KCNQ1 channel in several ways. This review aims to describe the current structural and functional knowledge about the cardiac KCNQ1/KCNE1 channel. In addition, we focus on the modulation of the KCNQ1/KCNE1 channel and its potential as a target therapeutic of LQTS.

Original languageEnglish (US)
Article number9440
Pages (from-to)1-23
Number of pages23
JournalInternational journal of molecular sciences
Volume21
Issue number24
DOIs
StatePublished - Dec 2 2020

Keywords

  • ATP
  • Cardiac arrhythmias
  • IKs
  • KCNE1
  • KCNQ1
  • Kv channel
  • Long QT syndrome
  • PIP
  • PKA
  • PUFA

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Insights into cardiac iks (Kcnq1/kcne1) channels regulation'. Together they form a unique fingerprint.

Cite this