Abstract
Lack of insight is a well-established phenomenon in schizophrenia, and has been associated with reduced rater-assessed functional performance but increased self-reported well-being in previous studies. The objective of this study was to examine factors that might influence insight (as assessed by the Insight and Treatment Attitudes Questionnaire [ITAQ] or PANSS item G12) and subjective quality-of-life (as assessed by Lehman QoL Interview [LQOLI]), using the large National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset. Uncooperativeness was assessed by PANSS item G8 ("Uncooperativeness"). In the analysis, we found significant moderating effects for insight on the relationships of subjective life satisfaction assessment to symptom severity (as assessed by CGI-S score), objective everyday functioning (as assessed by rater-administered Heinrichs-Carpenter Quality of Life scale), clinically rated uncooperativeness (as assessed by PANSS G8), and discontinuation of treatment for all causes (all P. <. 0.05 for statistical interaction between insight and subject QoL). Patients with chronic schizophrenia who reported being "pleased" or "delighted" on LQOLI were found to have significantly lower neurocognitive reasoning performance and poorer insight (ITAQ total score). Our findings underscore the importance of reducing cognitive and insight impairments for both treatment compliance and improved functional outcomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 127-132 |
| Number of pages | 6 |
| Journal | Schizophrenia Research: Cognition |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2015 |
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Keywords
- Insight into illness
- Neurocognition
- Patient-rated quality of life
- Schizophrenia
- Subjective well-being
ASJC Scopus subject areas
- Cognitive Neuroscience
- Psychiatry and Mental health
Cite this
Insight and subjective measures of quality of life in chronic schizophrenia. / Siu, Cynthia O.; Harvey, Philip D; Agid, Ofer; Waye, Mary; Brambilla, Carla; Choi, Wing Kit; Remington, Gary.
In: Schizophrenia Research: Cognition, Vol. 2, No. 3, 01.09.2015, p. 127-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insight and subjective measures of quality of life in chronic schizophrenia
AU - Siu, Cynthia O.
AU - Harvey, Philip D
AU - Agid, Ofer
AU - Waye, Mary
AU - Brambilla, Carla
AU - Choi, Wing Kit
AU - Remington, Gary
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Lack of insight is a well-established phenomenon in schizophrenia, and has been associated with reduced rater-assessed functional performance but increased self-reported well-being in previous studies. The objective of this study was to examine factors that might influence insight (as assessed by the Insight and Treatment Attitudes Questionnaire [ITAQ] or PANSS item G12) and subjective quality-of-life (as assessed by Lehman QoL Interview [LQOLI]), using the large National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset. Uncooperativeness was assessed by PANSS item G8 ("Uncooperativeness"). In the analysis, we found significant moderating effects for insight on the relationships of subjective life satisfaction assessment to symptom severity (as assessed by CGI-S score), objective everyday functioning (as assessed by rater-administered Heinrichs-Carpenter Quality of Life scale), clinically rated uncooperativeness (as assessed by PANSS G8), and discontinuation of treatment for all causes (all P. <. 0.05 for statistical interaction between insight and subject QoL). Patients with chronic schizophrenia who reported being "pleased" or "delighted" on LQOLI were found to have significantly lower neurocognitive reasoning performance and poorer insight (ITAQ total score). Our findings underscore the importance of reducing cognitive and insight impairments for both treatment compliance and improved functional outcomes.
AB - Lack of insight is a well-established phenomenon in schizophrenia, and has been associated with reduced rater-assessed functional performance but increased self-reported well-being in previous studies. The objective of this study was to examine factors that might influence insight (as assessed by the Insight and Treatment Attitudes Questionnaire [ITAQ] or PANSS item G12) and subjective quality-of-life (as assessed by Lehman QoL Interview [LQOLI]), using the large National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset. Uncooperativeness was assessed by PANSS item G8 ("Uncooperativeness"). In the analysis, we found significant moderating effects for insight on the relationships of subjective life satisfaction assessment to symptom severity (as assessed by CGI-S score), objective everyday functioning (as assessed by rater-administered Heinrichs-Carpenter Quality of Life scale), clinically rated uncooperativeness (as assessed by PANSS G8), and discontinuation of treatment for all causes (all P. <. 0.05 for statistical interaction between insight and subject QoL). Patients with chronic schizophrenia who reported being "pleased" or "delighted" on LQOLI were found to have significantly lower neurocognitive reasoning performance and poorer insight (ITAQ total score). Our findings underscore the importance of reducing cognitive and insight impairments for both treatment compliance and improved functional outcomes.
KW - Insight into illness
KW - Neurocognition
KW - Patient-rated quality of life
KW - Schizophrenia
KW - Subjective well-being
UR - http://www.scopus.com/inward/record.url?scp=84942190869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942190869&partnerID=8YFLogxK
U2 - 10.1016/j.scog.2015.05.002
DO - 10.1016/j.scog.2015.05.002
M3 - Article
AN - SCOPUS:84942190869
VL - 2
SP - 127
EP - 132
JO - Schizophrenia Research: Cognition
JF - Schizophrenia Research: Cognition
SN - 2215-0013
IS - 3
ER -