Insecticide Resistance in Areas Under Investigation by the International Centers of Excellence for Malaria Research: A Challenge for Malaria Control and Elimination

Martha L. Quiñones, Douglas E. Norris, Jan E. Conn, Marta Moreno, Thomas R. Burkot, Hugo Bugoro, John B. Keven, Robert Cooper, Guiyun Yan, Angel Rosas, Miriam Palomino, Martin J. Donnelly, Henry D. Mawejje, Alex Eapen, Jacqui Montgomery, Mamadou B. Coulibaly, John C Beier, Ashwani Kumar

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Scale-up of the main vector control interventions, residual insecticides sprayed on walls or structures and/or impregnated in bed nets, together with prompt diagnosis and effective treatment, have led to a global reduction in malaria transmission. However, resistance in vectors to almost all classes of insecticides, particularly to the synthetic pyrethroids, is posing a challenge to the recent trend of declining malaria. Ten International Centers of Excellence for Malaria Research (ICEMR) located in the most malaria-endemic regions of the world are currently addressing insecticide resistance in the main vector populations, which not only threaten hope for elimination in malaria-endemic countries but also may lead to reversal where notable reductions in malaria have been documented. This communication illustrates the current status of insecticide resistance with a focus on the countries where activities are ongoing for 9 out of the 10 ICEMRs. Most of the primary malaria vectors in the ICEMR countries exhibit insecticide resistance, albeit of varying magnitude, and spanning all mechanisms of resistance. New alternatives to the insecticides currently available are still to be fully developed for deployment. Integrated vector management principles need to be better understood and encouraged, and viable insecticide resistance management strategies need to be developed and implemented.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalThe American journal of tropical medicine and hygiene
Volume93
Issue number3
DOIs
StatePublished - Sep 1 2015

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Insecticide Resistance
Malaria
Research
Insecticides
Pyrethrins

ASJC Scopus subject areas

  • Medicine(all)

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Insecticide Resistance in Areas Under Investigation by the International Centers of Excellence for Malaria Research : A Challenge for Malaria Control and Elimination. / Quiñones, Martha L.; Norris, Douglas E.; Conn, Jan E.; Moreno, Marta; Burkot, Thomas R.; Bugoro, Hugo; Keven, John B.; Cooper, Robert; Yan, Guiyun; Rosas, Angel; Palomino, Miriam; Donnelly, Martin J.; Mawejje, Henry D.; Eapen, Alex; Montgomery, Jacqui; Coulibaly, Mamadou B.; Beier, John C; Kumar, Ashwani.

In: The American journal of tropical medicine and hygiene, Vol. 93, No. 3, 01.09.2015, p. 69-78.

Research output: Contribution to journalArticle

Quiñones, ML, Norris, DE, Conn, JE, Moreno, M, Burkot, TR, Bugoro, H, Keven, JB, Cooper, R, Yan, G, Rosas, A, Palomino, M, Donnelly, MJ, Mawejje, HD, Eapen, A, Montgomery, J, Coulibaly, MB, Beier, JC & Kumar, A 2015, 'Insecticide Resistance in Areas Under Investigation by the International Centers of Excellence for Malaria Research: A Challenge for Malaria Control and Elimination', The American journal of tropical medicine and hygiene, vol. 93, no. 3, pp. 69-78. https://doi.org/10.4269/ajtmh.14-0844
Quiñones, Martha L. ; Norris, Douglas E. ; Conn, Jan E. ; Moreno, Marta ; Burkot, Thomas R. ; Bugoro, Hugo ; Keven, John B. ; Cooper, Robert ; Yan, Guiyun ; Rosas, Angel ; Palomino, Miriam ; Donnelly, Martin J. ; Mawejje, Henry D. ; Eapen, Alex ; Montgomery, Jacqui ; Coulibaly, Mamadou B. ; Beier, John C ; Kumar, Ashwani. / Insecticide Resistance in Areas Under Investigation by the International Centers of Excellence for Malaria Research : A Challenge for Malaria Control and Elimination. In: The American journal of tropical medicine and hygiene. 2015 ; Vol. 93, No. 3. pp. 69-78.
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