Abstract
The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. Inotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular end diastolic pressure, shift to an augmented function curve in work pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5 to 15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject.
Original language | English |
---|---|
Title of host publication | CATHETER.CARDIOVASC.DIAGN. |
Pages | 47-57 |
Number of pages | 11 |
Volume | 1 |
Edition | 1 |
State | Published - Dec 1 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)