Abstract
The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. Inotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular end diastolic pressure, shift to an augmented function curve in work pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5 to 15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject.
| Original language | English |
|---|---|
| Title of host publication | CATHETER.CARDIOVASC.DIAGN. |
| Pages | 47-57 |
| Number of pages | 11 |
| Volume | 1 |
| Edition | 1 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Inotropic action of tolbutamide on human myocardium. / Hildner, F. J.; Yeh, B. K.; Javier, R. P.; Fester, A.; Samet, P.
CATHETER.CARDIOVASC.DIAGN.. Vol. 1 1. ed. 1975. p. 47-57.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Inotropic action of tolbutamide on human myocardium
AU - Hildner, F. J.
AU - Yeh, B. K.
AU - Javier, R. P.
AU - Fester, A.
AU - Samet, P.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. Inotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular end diastolic pressure, shift to an augmented function curve in work pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5 to 15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject.
AB - The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. Inotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular end diastolic pressure, shift to an augmented function curve in work pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5 to 15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject.
UR - http://www.scopus.com/inward/record.url?scp=0016720152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016720152&partnerID=8YFLogxK
M3 - Chapter
VL - 1
SP - 47
EP - 57
BT - CATHETER.CARDIOVASC.DIAGN.
ER -