Inotropic action of tolbutamide on human myocardium

F. J. Hildner, B. K. Yeh, R. P. Javier, A. Fester, P. Samet

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. Inotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular end diastolic pressure, shift to an augmented function curve in work pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5 to 15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject.

Original languageEnglish
Title of host publicationCATHETER.CARDIOVASC.DIAGN.
Number of pages11
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Hildner, F. J., Yeh, B. K., Javier, R. P., Fester, A., & Samet, P. (1975). Inotropic action of tolbutamide on human myocardium. In CATHETER.CARDIOVASC.DIAGN. (1 ed., Vol. 1, pp. 47-57)