Inotropic action of tolbutamide on human myocardium

F. J. Hildner, B. K. Yeh, R. P. Javier, A. Fester, P. Samet

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

The inotropic action of tolbutamide previously demonstrated in vitro was evaluated in 15 nondiabetic subjects during diagnostic cardiac catheterization. Following bolus injection of 250 mg of tolbutamide intravenously, a rise of serum insulin and a slight fall of serum potassium were observed. Inotropic response was determined from significant fall in PEP/LVET ratio, significant fall of left ventricular end diastolic pressure, shift to an augmented function curve in work pressure relationships, and prominent rise of dP/dt values at comparable heart rates. The inotropic effect was greatest at 5 to 15 min with return to near control values at 30 min. An unusually marked inotropic response was observed in one subject.

Original languageEnglish
Title of host publicationCATHETER.CARDIOVASC.DIAGN.
Pages47-57
Number of pages11
Volume1
Edition1
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Inotropic action of tolbutamide on human myocardium'. Together they form a unique fingerprint.

  • Cite this

    Hildner, F. J., Yeh, B. K., Javier, R. P., Fester, A., & Samet, P. (1975). Inotropic action of tolbutamide on human myocardium. In CATHETER.CARDIOVASC.DIAGN. (1 ed., Vol. 1, pp. 47-57)