Abstract
The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the inositide family. They represent a new frontier with both novel targets within the cell and novel modes of action. This includes the proposed pyrophosphorylation of a unique subset of proteins. We review recent insights into the structures of these molecules and the properties of the enzymes which regulate their concentration. These enzymes also act independently of their catalytic activity via protein-protein interactions. This unique combination of enzymes and products has an important role in diverse cellular processes including vesicle trafficking, endo- and exocytosis, apoptosis, telomere length regulation, chromatin hyperrecombination, the response to osmotic stress, and elements of nucleolar function.
| Original language | English |
|---|---|
| Pages (from-to) | 3851-3871 |
| Number of pages | 21 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 66 |
| Issue number | 24 |
| DOIs | |
| State | Published - Jan 1 2009 |
| Externally published | Yes |
Fingerprint
Keywords
- Diphosphoinositol pentakisphosphate kinase
- Diphosphoinositol phosphate
- Diphosphoinositol polyphosphate phosphohydrolase
- Inositol hexakisphosphate kinase
- Inositol phosphate
- Inositol pyrophosphate
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Molecular Medicine
- Pharmacology
- Cellular and Molecular Neuroscience
Cite this
Inositol pyrophosphates : Structure, enzymology and function. / Barker, Christopher John; Illies, Christopher; Gaboardi, Gian Carlo; Berggren, Per Olof.
In: Cellular and Molecular Life Sciences, Vol. 66, No. 24, 01.01.2009, p. 3851-3871.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inositol pyrophosphates
T2 - Structure, enzymology and function
AU - Barker, Christopher John
AU - Illies, Christopher
AU - Gaboardi, Gian Carlo
AU - Berggren, Per Olof
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the inositide family. They represent a new frontier with both novel targets within the cell and novel modes of action. This includes the proposed pyrophosphorylation of a unique subset of proteins. We review recent insights into the structures of these molecules and the properties of the enzymes which regulate their concentration. These enzymes also act independently of their catalytic activity via protein-protein interactions. This unique combination of enzymes and products has an important role in diverse cellular processes including vesicle trafficking, endo- and exocytosis, apoptosis, telomere length regulation, chromatin hyperrecombination, the response to osmotic stress, and elements of nucleolar function.
AB - The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the inositide family. They represent a new frontier with both novel targets within the cell and novel modes of action. This includes the proposed pyrophosphorylation of a unique subset of proteins. We review recent insights into the structures of these molecules and the properties of the enzymes which regulate their concentration. These enzymes also act independently of their catalytic activity via protein-protein interactions. This unique combination of enzymes and products has an important role in diverse cellular processes including vesicle trafficking, endo- and exocytosis, apoptosis, telomere length regulation, chromatin hyperrecombination, the response to osmotic stress, and elements of nucleolar function.
KW - Diphosphoinositol pentakisphosphate kinase
KW - Diphosphoinositol phosphate
KW - Diphosphoinositol polyphosphate phosphohydrolase
KW - Inositol hexakisphosphate kinase
KW - Inositol phosphate
KW - Inositol pyrophosphate
UR - http://www.scopus.com/inward/record.url?scp=70849090308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70849090308&partnerID=8YFLogxK
U2 - 10.1007/s00018-009-0115-2
DO - 10.1007/s00018-009-0115-2
M3 - Article
VL - 66
SP - 3851
EP - 3871
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 24
ER -