Inositol hexakisphosphate promotes dynamin I-mediated endocytosis

Marianne Høy, Alexander M. Efanov, Alejandro M. Bertorello, Sergei V. Zaitsev, Hervør L. Olsen, Krister Bokvist, Barbara Leibiger, Ingo B. Leibiger, Jean Zwiller, Per Olof Berggren, Jesper Gromada

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Membrane homeostasis is maintained by exocytosis and endocytosis. The molecular mechanisms regulating the interplay between these two processes are not clear. Inositol hexakisphosphate (InsP6) is under metabolic control and serves as a signal in the pancreatic β cell stimulus-secretion coupling by increasing Ca2+-channel activity and insulin exocytosis. We now show that InsP6 also promotes dynamin I-mediated endocytosis in the pancreatic β cell. This effect of InsP6 depends on calcineurin-induced dephosphorylation and is accounted for by both activation of protein kinase C and inhibition of the phosphoinositide phosphatase synaptojanin and thereby formation of phosphatidylinositol 4,5-bisphosphate. In regulating both exocytosis and endocytosis, InsP6 thus may have an essential integral role in membrane trafficking.

Original languageEnglish (US)
Pages (from-to)6773-6777
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number10
DOIs
StatePublished - May 14 2002

ASJC Scopus subject areas

  • General

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