Innexins form two types of channels

Li Bao, Stuart Samuels, Silviu Locovei, Eduardo R. Macagno, Kenneth J Muller, Gerhard Dahl

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Injury to the central nervous system triggers glial calcium waves in both vertebrates and invertebrates. In vertebrates the pannexin1 ATP-release channel appears to provide for calcium wave initiation and propagation. The innexins, which form invertebrate gap junctions and have sequence similarity with the pannexins, are candidates to form non-junctional membrane channels. Two leech innexins previously demonstrated in glia were expressed in frog oocytes. In addition to making gap junctions, innexins also formed non-junctional membrane channels with properties similar to those of pannexons. In addition, carbenoxolone reversibly blocked the loss of carboxyfluorescein dye into the bath from the giant glial cells in the connectives of the leech nerve cord, which are known to express the innexins we assayed.

Original languageEnglish
Pages (from-to)5703-5708
Number of pages6
JournalFEBS Letters
Volume581
Issue number29
DOIs
StatePublished - Dec 11 2007

Fingerprint

Neuroglia
Leeches
Calcium Signaling
Gap Junctions
Invertebrates
Ion Channels
Vertebrates
Carbenoxolone
Calcium
Neurology
Giant Cells
Baths
Anura
Oocytes
Coloring Agents
Central Nervous System
Adenosine Triphosphate
Wounds and Injuries
6-carboxyfluorescein

Keywords

  • ATP
  • Calcium wave
  • Evolution
  • Glia
  • Innexin
  • Pannexin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Bao, L., Samuels, S., Locovei, S., Macagno, E. R., Muller, K. J., & Dahl, G. (2007). Innexins form two types of channels. FEBS Letters, 581(29), 5703-5708. https://doi.org/10.1016/j.febslet.2007.11.030

Innexins form two types of channels. / Bao, Li; Samuels, Stuart; Locovei, Silviu; Macagno, Eduardo R.; Muller, Kenneth J; Dahl, Gerhard.

In: FEBS Letters, Vol. 581, No. 29, 11.12.2007, p. 5703-5708.

Research output: Contribution to journalArticle

Bao, L, Samuels, S, Locovei, S, Macagno, ER, Muller, KJ & Dahl, G 2007, 'Innexins form two types of channels', FEBS Letters, vol. 581, no. 29, pp. 5703-5708. https://doi.org/10.1016/j.febslet.2007.11.030
Bao L, Samuels S, Locovei S, Macagno ER, Muller KJ, Dahl G. Innexins form two types of channels. FEBS Letters. 2007 Dec 11;581(29):5703-5708. https://doi.org/10.1016/j.febslet.2007.11.030
Bao, Li ; Samuels, Stuart ; Locovei, Silviu ; Macagno, Eduardo R. ; Muller, Kenneth J ; Dahl, Gerhard. / Innexins form two types of channels. In: FEBS Letters. 2007 ; Vol. 581, No. 29. pp. 5703-5708.
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