Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide

L. Edvinsson; R. Håkanson; S. Steen; F. Sundler; R. Uddman; C. Wahlestedt

doi:10.1016/0167-0115(85)90188-0

Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide

L. Edvinsson, R. Håkanson, S. Steen, F. Sundler, R. Uddman, C. Wahlestedt

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α₁-adrenoceptors and omental veins with a mixture of α₁- and α₂-adrenoceptors. NPY at a concentration of 10^-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10^-8 M shifted the NA concentration response curve to the left in arteries (pD₂ = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F_2α (PGF_2α). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.

Original language	English (US)
Pages (from-to)	67-79
Number of pages	13
Journal	Regulatory Peptides
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0167-0115(85)90188-0
State	Published - Sep 1985
Externally published	Yes

Keywords

arteries and veins
neuropeptides
noradrenaline
sympathetic nerves
vasomotor response

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Neuroscience(all)

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10.1016/0167-0115(85)90188-0

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title = "Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide",

abstract = "Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F2α (PGF2α). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.",

keywords = "arteries and veins, neuropeptides, noradrenaline, sympathetic nerves, vasomotor response",

author = "L. Edvinsson and R. H{\aa}kanson and S. Steen and F. Sundler and R. Uddman and C. Wahlestedt",

note = "Funding Information: Supported by grants from the Swedish Medical Research Council (No. 5958, 6859) and the Swedish Association against Heart and Chest Diseases and the Magnus Bergvall Foundation. We are grateful to Ingela Nilsson and Birgitta Takolander for typing the manuscript.",

year = "1985",

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doi = "10.1016/0167-0115(85)90188-0",

language = "English (US)",

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T1 - Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide

AU - Edvinsson, L.

AU - Håkanson, R.

AU - Steen, S.

AU - Sundler, F.

AU - Uddman, R.

AU - Wahlestedt, C.

N1 - Funding Information: Supported by grants from the Swedish Medical Research Council (No. 5958, 6859) and the Swedish Association against Heart and Chest Diseases and the Magnus Bergvall Foundation. We are grateful to Ingela Nilsson and Birgitta Takolander for typing the manuscript.

PY - 1985/9

Y1 - 1985/9

N2 - Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F2α (PGF2α). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.

AB - Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F2α (PGF2α). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.

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KW - vasomotor response

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Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide

Abstract

Keywords

ASJC Scopus subject areas

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