Abstract
Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F2α (PGF2α). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.
| Original language | English |
|---|---|
| Pages (from-to) | 67-79 |
| Number of pages | 13 |
| Journal | Regulatory Peptides |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1985 |
| Externally published | Yes |
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Keywords
- arteries and veins
- neuropeptides
- noradrenaline
- sympathetic nerves
- vasomotor response
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Neuroscience(all)
Cite this
Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide. / Edvinsson, L.; Håkanson, R.; Steen, S.; Sundler, F.; Uddman, R.; Wahlestedt, Claes R.
In: Regulatory Peptides, Vol. 12, No. 1, 01.01.1985, p. 67-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide
AU - Edvinsson, L.
AU - Håkanson, R.
AU - Steen, S.
AU - Sundler, F.
AU - Uddman, R.
AU - Wahlestedt, Claes R
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F2α (PGF2α). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.
AB - Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F2α (PGF2α). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.
KW - arteries and veins
KW - neuropeptides
KW - noradrenaline
KW - sympathetic nerves
KW - vasomotor response
UR - http://www.scopus.com/inward/record.url?scp=0022413573&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022413573&partnerID=8YFLogxK
U2 - 10.1016/0167-0115(85)90188-0
DO - 10.1016/0167-0115(85)90188-0
M3 - Article
C2 - 2416012
AN - SCOPUS:0022413573
VL - 12
SP - 67
EP - 79
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
IS - 1
ER -