Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide

L. Edvinsson, R. Håkanson, S. Steen, F. Sundler, R. Uddman, Claes R Wahlestedt

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F (PGF). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.

Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalRegulatory Peptides
Volume12
Issue number1
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Neuropeptide Y
Vasoactive Intestinal Peptide
Substance P
Veins
Norepinephrine
Arteries
Adrenergic Receptors
Fibers
Nerve Fibers
Dinoprost
Adrenergic Fibers
Constriction
Experiments

Keywords

  • arteries and veins
  • neuropeptides
  • noradrenaline
  • sympathetic nerves
  • vasomotor response

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide. / Edvinsson, L.; Håkanson, R.; Steen, S.; Sundler, F.; Uddman, R.; Wahlestedt, Claes R.

In: Regulatory Peptides, Vol. 12, No. 1, 01.01.1985, p. 67-79.

Research output: Contribution to journalArticle

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