Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide

L. Edvinsson, R. Håkanson, S. Steen, F. Sundler, R. Uddman, C. Wahlestedt

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Human omental arteries and veins are supplied with nerve fibers containing noradrenaline (NA) and neuropeptide Y (NPY); these two agents probably co-exist in perivascular sympathetic nerve fibers. Substance P (SP)- or vasoactive intestinal peptide (VIP)-containing fibers could not be detected. In studies on isolated omental vessels NA produced constriction. The results of blockade experiments suggest that human omental arteries are equipped predominantly with α1-adrenoceptors and omental veins with a mixture of α1- and α2-adrenoceptors. NPY at a concentration of 10-7 M or higher had a weak contractile effect on veins and virtually no effect on arteries. NPY at a concentration of 3 × 10-8 M shifted the NA concentration response curve to the left in arteries (pD2 = 5.8 for NA versus 6.6. for NA in the presence of NPY; P < 0.001) but not in veins. Both SP and VIP relaxed arteries precontracted with NA or prostaglandin F (PGF). The potency of SP as a relaxant agent was similar in arteries and veins; the effect of VIP was elicited at lower concentrations in veins than in arteries.

Original languageEnglish (US)
Pages (from-to)67-79
Number of pages13
JournalRegulatory Peptides
Issue number1
StatePublished - Sep 1985



  • arteries and veins
  • neuropeptides
  • noradrenaline
  • sympathetic nerves
  • vasomotor response

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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