Abstract
In just a few years, the view of glycogen synthase kinase-3 (GSK3) has been transformed from an obscure enzyme seldom encountered in the immune literature to one implicated in an improbably large number of roles. GSK3 is a crucial regulator of the balance between pro- and anti-inflammatory cytokine production in both the periphery and the central nervous system, so that GSK3 inhibitors such as lithium can diminish inflammation. GSK3 influences T-cell proliferation, differentiation and survival. Many effects stem from GSK3 regulation of critical transcription factors, such as NF-κB, NFAT and STATs. These discoveries led to the rapid application of GSK3 inhibitors to animal models of sepsis, arthritis, colitis, multiple sclerosis and others, demonstrating their potential for therapeutic intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 24-31 |
| Number of pages | 8 |
| Journal | Trends in Immunology |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2010 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). / Beurel, Eleonore; Michalek, Suzanne M.; Jope, Richard S.
In: Trends in Immunology, Vol. 31, No. 1, 01.01.2010, p. 24-31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
AU - Beurel, Eleonore
AU - Michalek, Suzanne M.
AU - Jope, Richard S
PY - 2010/1/1
Y1 - 2010/1/1
N2 - In just a few years, the view of glycogen synthase kinase-3 (GSK3) has been transformed from an obscure enzyme seldom encountered in the immune literature to one implicated in an improbably large number of roles. GSK3 is a crucial regulator of the balance between pro- and anti-inflammatory cytokine production in both the periphery and the central nervous system, so that GSK3 inhibitors such as lithium can diminish inflammation. GSK3 influences T-cell proliferation, differentiation and survival. Many effects stem from GSK3 regulation of critical transcription factors, such as NF-κB, NFAT and STATs. These discoveries led to the rapid application of GSK3 inhibitors to animal models of sepsis, arthritis, colitis, multiple sclerosis and others, demonstrating their potential for therapeutic intervention.
AB - In just a few years, the view of glycogen synthase kinase-3 (GSK3) has been transformed from an obscure enzyme seldom encountered in the immune literature to one implicated in an improbably large number of roles. GSK3 is a crucial regulator of the balance between pro- and anti-inflammatory cytokine production in both the periphery and the central nervous system, so that GSK3 inhibitors such as lithium can diminish inflammation. GSK3 influences T-cell proliferation, differentiation and survival. Many effects stem from GSK3 regulation of critical transcription factors, such as NF-κB, NFAT and STATs. These discoveries led to the rapid application of GSK3 inhibitors to animal models of sepsis, arthritis, colitis, multiple sclerosis and others, demonstrating their potential for therapeutic intervention.
UR - http://www.scopus.com/inward/record.url?scp=73149097234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73149097234&partnerID=8YFLogxK
U2 - 10.1016/j.it.2009.09.007
DO - 10.1016/j.it.2009.09.007
M3 - Article
C2 - 19836308
AN - SCOPUS:73149097234
VL - 31
SP - 24
EP - 31
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 1
ER -