TY - JOUR
T1 - Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
AU - Beurel, Eléonore
AU - Michalek, Suzanne M.
AU - Jope, Richard S.
N1 - Funding Information:
Our work is supported by a Young Investigator Award from NARSAD (to E.B.) and National Institutes of Health grants MH38752 (to R.S.J.) and DE09081 (to S.M.). We apologize to investigators whose work could not be cited because of space limitations.
PY - 2010/1
Y1 - 2010/1
N2 - In just a few years, the view of glycogen synthase kinase-3 (GSK3) has been transformed from an obscure enzyme seldom encountered in the immune literature to one implicated in an improbably large number of roles. GSK3 is a crucial regulator of the balance between pro- and anti-inflammatory cytokine production in both the periphery and the central nervous system, so that GSK3 inhibitors such as lithium can diminish inflammation. GSK3 influences T-cell proliferation, differentiation and survival. Many effects stem from GSK3 regulation of critical transcription factors, such as NF-κB, NFAT and STATs. These discoveries led to the rapid application of GSK3 inhibitors to animal models of sepsis, arthritis, colitis, multiple sclerosis and others, demonstrating their potential for therapeutic intervention.
AB - In just a few years, the view of glycogen synthase kinase-3 (GSK3) has been transformed from an obscure enzyme seldom encountered in the immune literature to one implicated in an improbably large number of roles. GSK3 is a crucial regulator of the balance between pro- and anti-inflammatory cytokine production in both the periphery and the central nervous system, so that GSK3 inhibitors such as lithium can diminish inflammation. GSK3 influences T-cell proliferation, differentiation and survival. Many effects stem from GSK3 regulation of critical transcription factors, such as NF-κB, NFAT and STATs. These discoveries led to the rapid application of GSK3 inhibitors to animal models of sepsis, arthritis, colitis, multiple sclerosis and others, demonstrating their potential for therapeutic intervention.
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U2 - 10.1016/j.it.2009.09.007
DO - 10.1016/j.it.2009.09.007
M3 - Review article
C2 - 19836308
AN - SCOPUS:73149097234
VL - 31
SP - 24
EP - 31
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 1
ER -