Injury Mechanisms in the Ischaemic Penumbra –Approaches to Neuroprotection in Acute Ischaemic Stroke

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Focal ischaemic injury in the brain is related to both the intensity and the duration of the decrement in cerebral blood flow. The ischaemic penumbra, an area characterised by levels of blood flow slightly greater than the ischaemic core itself, is a zone exhibiting preserved or even accentuated metabolic rate, apparently driven by recurrent ischaemic depolarisations. Excitatory amino acid neurotransmitter release and raised levels of oxygen radical activity occur within it. The penumbra represents that region of the focal ischaemic lesion which is potentially amenable to metabolic neuroprotection, and several classes of neuroprotective agents are currently under clinical evaluation for stroke. As the untreated penumbra deteriorates over time, animal studies indicate that therapy should be administered within a therapeutic window of no more than 3-6 h from stroke onset if it is to be successful.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalCerebrovascular Diseases
StatePublished - Jan 1 1997


  • Acute ischaemic stroke
  • Glutamate release
  • Ischaemic penumbra
  • Middle cerebral artery occlusion
  • Neuroprotection

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Injury Mechanisms in the Ischaemic Penumbra –Approaches to Neuroprotection in Acute Ischaemic Stroke'. Together they form a unique fingerprint.

Cite this