Injectable, cellular-scale optoelectronics with applications for wireless optogenetics

Tae Il Kim, Jordan G. McCall, Yei Hwan Jung, Xian Huang, Edward R. Siuda, Yuhang Li, Jizhou Song, Young Min Song, Hsuan An Pao, Rak Hwan Kim, Chaofeng Lu, Sung Dan Lee, Il Sun Song, Gunchul Shin, Ream Al-Hasani, Stanley Kim, Meng Peun Tan, Yonggang Huang, Fiorenzo G. Omenetto, John A. RogersMichael R. Bruchas

Research output: Contribution to journalArticle

577 Citations (Scopus)

Abstract

Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomedical science and engineering.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalScience
Volume340
Issue number6129
DOIs
StatePublished - Apr 12 2013

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Neuroscience
Animals
Organs
Scientific Discovery
Semiconductors
Sensor

ASJC Scopus subject areas

  • General
  • History and Philosophy of Science

Cite this

Kim, T. I., McCall, J. G., Jung, Y. H., Huang, X., Siuda, E. R., Li, Y., ... Bruchas, M. R. (2013). Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science, 340(6129), 211-216. https://doi.org/10.1126/science.1232437

Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. / Kim, Tae Il; McCall, Jordan G.; Jung, Yei Hwan; Huang, Xian; Siuda, Edward R.; Li, Yuhang; Song, Jizhou; Song, Young Min; Pao, Hsuan An; Kim, Rak Hwan; Lu, Chaofeng; Lee, Sung Dan; Song, Il Sun; Shin, Gunchul; Al-Hasani, Ream; Kim, Stanley; Tan, Meng Peun; Huang, Yonggang; Omenetto, Fiorenzo G.; Rogers, John A.; Bruchas, Michael R.

In: Science, Vol. 340, No. 6129, 12.04.2013, p. 211-216.

Research output: Contribution to journalArticle

Kim, TI, McCall, JG, Jung, YH, Huang, X, Siuda, ER, Li, Y, Song, J, Song, YM, Pao, HA, Kim, RH, Lu, C, Lee, SD, Song, IS, Shin, G, Al-Hasani, R, Kim, S, Tan, MP, Huang, Y, Omenetto, FG, Rogers, JA & Bruchas, MR 2013, 'Injectable, cellular-scale optoelectronics with applications for wireless optogenetics', Science, vol. 340, no. 6129, pp. 211-216. https://doi.org/10.1126/science.1232437
Kim TI, McCall JG, Jung YH, Huang X, Siuda ER, Li Y et al. Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science. 2013 Apr 12;340(6129):211-216. https://doi.org/10.1126/science.1232437
Kim, Tae Il ; McCall, Jordan G. ; Jung, Yei Hwan ; Huang, Xian ; Siuda, Edward R. ; Li, Yuhang ; Song, Jizhou ; Song, Young Min ; Pao, Hsuan An ; Kim, Rak Hwan ; Lu, Chaofeng ; Lee, Sung Dan ; Song, Il Sun ; Shin, Gunchul ; Al-Hasani, Ream ; Kim, Stanley ; Tan, Meng Peun ; Huang, Yonggang ; Omenetto, Fiorenzo G. ; Rogers, John A. ; Bruchas, Michael R. / Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. In: Science. 2013 ; Vol. 340, No. 6129. pp. 211-216.
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