Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response

Jean D. Boyer, Sanjeev Kumar, Tara Robinson, Rose Parkinson, Ling Wu, Mark Lewis, David Watkins, David B. Weiner

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In the present era of increasing resistance of human immunodeficiency virus (HIV) to antiviral drugs, exploration of adjunct therapies directed at immune responses in combination with antiretroviral drugs may be of value for the treatment of acquired immunodeficiency syndrome. In this study, we designed a model for immune therapy using SIVmac251 infection in rhesus macaques. We explored the outcomes of primary infection on viral loads and the resulting T-cell immune responses in primates. The SIV-infected rhesus macaque model exhibited features similar to those observed in HIV-1 infection of humans. Major histocompatibility complex (MHC) segregation with viral loads were found to associate with viral containment and hence the duration of the disease-free latency period. Thus a better understanding of the relative roles of MHC class I allele in control of viral replication may provide important information for prophylactic or therapeutic vaccine designs. Mamu-A01 is significantly associated with higher immune response and control of viral replication. This allele is frequent in rhesus macaques of Indian origin (22%). Interestingly, Mamu-B01 (26% animals) was associated with lower immune responses and higher viral loads. Another allele, A08 was also predominantly present in 37% of the animals in this study. We observed higher viral replication in individual SIV-infected rhesus monkeys that did not demonstrate strong cellular immune responses. The results are important for understanding SIV disease progression in different MHC Mamu alleles and also for improving the interpretation and quality of pre-clinical studies in rhesus monkeys.

Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalJournal of Medical Primatology
Volume35
Issue number4-5
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

viral load
Macaca mulatta
Viral Load
T-lymphocytes
immune response
T-Lymphocytes
major histocompatibility complex
therapeutics
virus replication
Major Histocompatibility Complex
Alleles
alleles
Infection
infection
antiviral agents
Therapeutics
acquired immunodeficiency syndrome
Human immunodeficiency virus
Virus Diseases
Human immunodeficiency virus 1

Keywords

  • ART
  • CD4 T cells
  • FTC PMPA
  • IFN-γ
  • SIV

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response. / Boyer, Jean D.; Kumar, Sanjeev; Robinson, Tara; Parkinson, Rose; Wu, Ling; Lewis, Mark; Watkins, David; Weiner, David B.

In: Journal of Medical Primatology, Vol. 35, No. 4-5, 01.08.2006, p. 202-209.

Research output: Contribution to journalArticle

Boyer, Jean D. ; Kumar, Sanjeev ; Robinson, Tara ; Parkinson, Rose ; Wu, Ling ; Lewis, Mark ; Watkins, David ; Weiner, David B. / Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response. In: Journal of Medical Primatology. 2006 ; Vol. 35, No. 4-5. pp. 202-209.
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