Initial report of a genome search for the affective disorder predisposition gene in the Old Order Amish pedigrees: Chromosomes 1 and 11

D. S. Gerhard, M. C. LaBuda, S. D. Bland, C. Allen, J. A. Egeland, D. L. Pauls

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Family data have suggested that some forms of major affective disorder are genetic. Certain of the Old Order Amish pedigrees have a familial form of the disease. In this report we present the results of genetic analyses under autosomal dominant mode of transmission with reduced penetrance and three different disease hierarchies. The pedigrees were genotyped with 28 markers from chromosome 1 and 23 markers from chromosomes 11. None of the markers result in a significantly positive lod score.

Original languageEnglish (US)
Pages (from-to)398-404
Number of pages7
JournalAmerican journal of medical genetics
Volume54
Issue number4
DOIs
StatePublished - Dec 1 1994

Keywords

  • chromosome 1
  • chromosome 11
  • linkage analysis
  • major affective disorder
  • Old Order Amish

ASJC Scopus subject areas

  • Genetics(clinical)

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