Initial report of a genome search for the affective disorder predisposition gene in the Old Order Amish pedigrees: Chromosomes 1 and 11

D. S. Gerhard; M. C. LaBuda; S. D. Bland; C. Allen; J. A. Egeland; D. L. Pauls

doi:10.1002/ajmg.1320540421

Initial report of a genome search for the affective disorder predisposition gene in the Old Order Amish pedigrees: Chromosomes 1 and 11

D. S. Gerhard, M. C. LaBuda, S. D. Bland, C. Allen, J. A. Egeland, D. L. Pauls

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Family data have suggested that some forms of major affective disorder are genetic. Certain of the Old Order Amish pedigrees have a familial form of the disease. In this report we present the results of genetic analyses under autosomal dominant mode of transmission with reduced penetrance and three different disease hierarchies. The pedigrees were genotyped with 28 markers from chromosome 1 and 23 markers from chromosomes 11. None of the markers result in a significantly positive lod score.

Original language	English (US)
Pages (from-to)	398-404
Number of pages	7
Journal	American journal of medical genetics
Volume	54
Issue number	4
DOIs	https://doi.org/10.1002/ajmg.1320540421
State	Published - 1994

Keywords

chromosome 1
chromosome 11
linkage analysis
major affective disorder
Old Order Amish

ASJC Scopus subject areas

Genetics(clinical)

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AU - Allen, C.

AU - Egeland, J. A.

AU - Pauls, D. L.

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KW - Old Order Amish

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Initial report of a genome search for the affective disorder predisposition gene in the Old Order Amish pedigrees: Chromosomes 1 and 11

Abstract

Keywords

ASJC Scopus subject areas

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