Inhibitory influences of envelope glycoproteins of HIV-1 on normal immune responses

Narendra Chirmule, V. Kalyanaraman, Naoki Oyaizu, Savita Pahwa

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Infection with the human immunodeficiency virus (HIV-1) leads to a wide range of immunological abnormalities. We have shown that native envelope glycoproteins (gp120) of HIV-1 inhibit antigen-specific and anti-CD3 induced lymphoproliferation of normal lymphocytes. We have demonstrated that gp120 binds to CD4 positive T lymphocytes and is internalized. These studies suggest that interaction of gp120 with the CD4 receptor may be sufficient to inhibit antigen-specific T cell responses that are mediated via the CD3-Ti receptor complex. Such an event could represent another mechanism by which the overall immune function of the CD4 positive T lymphocyte is depressed and may be relevant in planning investigations on the ongoing vaccine trial involving envelope glycoproteins.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume1
Issue number5
StatePublished - Oct 1988
Externally publishedYes

Keywords

  • CD3
  • CD4
  • HIV-1
  • Immune suppression
  • gp120

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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