Inhibitory effects of naltrexone on the induction of parental behavior in juvenile rats

Julia Zaias, L. Okimoto, A. Trivedi, P. E. Mann, R. S. Bridges

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Juvenile rats are rapidly responsive to pups soon after weaning, displaying maternal-like behaviors such as liking, retrieving, grouping, and crouching over pups. As juveniles reach 30 days of age, they become less responsive to pups and show increased latencies to display the same parental behaviors. In light of previous data implicating opiates in the display of ongoing maternal behavior, we administered naltrexone, a long-acting opiate antagonist, beginning 5 and 9 days prior to and continuing throughout the period of behavioral testing, which started at 26 or 30 days of age. Male and female juveniles treated with 10 mg/kg of naltrexone SC for 9 days (days 21 to 29 of age) prior to and during behavioral testing (days 30 to 37) showed longer latencies to retrieve, group, and crouch over pups than did the vehicle-injected controls. These results suggest that opioids may have a stimuiatory role in parental behavior during this prepubertal period.

Original languageEnglish
Pages (from-to)987-993
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume53
Issue number4
DOIs
StatePublished - Apr 1 1996
Externally publishedYes

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Opiate Alkaloids
Maternal Behavior
Naltrexone
Rats
Testing
Weaning
Opioid Analgesics
Display devices

Keywords

  • Juvenile rats
  • Naltrexone
  • Opiate antagonist
  • Opioid
  • Parental behavior
  • Prepubertal

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Inhibitory effects of naltrexone on the induction of parental behavior in juvenile rats. / Zaias, Julia; Okimoto, L.; Trivedi, A.; Mann, P. E.; Bridges, R. S.

In: Pharmacology Biochemistry and Behavior, Vol. 53, No. 4, 01.04.1996, p. 987-993.

Research output: Contribution to journalArticle

Zaias, Julia ; Okimoto, L. ; Trivedi, A. ; Mann, P. E. ; Bridges, R. S. / Inhibitory effects of naltrexone on the induction of parental behavior in juvenile rats. In: Pharmacology Biochemistry and Behavior. 1996 ; Vol. 53, No. 4. pp. 987-993.
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