Inhibitory activity of four analogs of luteinizing hormone releasing hormone in vivo

L. Ferland, F. Labrie, D. H. Coy, E. J. Coy, A. V. Schally

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Four analogs of luteinizing hormone releasing hormone (LH RH), [des His 2, D Ala 6] LH RH, [des His 2, D Ala 6, des Gly NH 2 10] LH RH ethylamide, [des His 2, D Leu 6] LH RH, and [D Phe 2, D Leu 6] LH RH, at 300 fold molar ratios analog/LH RH) led to an almost complete inhibition of LH response to LH RH in anesthetized 4 day cycling rats on the afternoon of proestrus. At a 75 fold molar ratio, [des His 2,D Ala 6] LH RH still inhibited the LH RH induced LH release by 50%. The ethylamide substitution at the COOH terminus of [des His 2,D Ala 6] LH RH did not significantly improve the inhibitory activity of the molecule.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalUnknown Journal
Volume26
Issue number9
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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