Inhibitory activity of four analogs of luteinizing hormone releasing hormone in vivo

L. Ferland, F. Labrie, D. H. Coy, E. J. Coy, Andrew V Schally

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Four analogs of luteinizing hormone releasing hormone (LH RH), [des His 2, D Ala 6] LH RH, [des His 2, D Ala 6, des Gly NH 2 10] LH RH ethylamide, [des His 2, D Leu 6] LH RH, and [D Phe 2, D Leu 6] LH RH, at 300 fold molar ratios analog/LH RH) led to an almost complete inhibition of LH response to LH RH in anesthetized 4 day cycling rats on the afternoon of proestrus. At a 75 fold molar ratio, [des His 2,D Ala 6] LH RH still inhibited the LH RH induced LH release by 50%. The ethylamide substitution at the COOH terminus of [des His 2,D Ala 6] LH RH did not significantly improve the inhibitory activity of the molecule.

Original languageEnglish
Pages (from-to)889-893
Number of pages5
JournalFertility and Sterility
Volume26
Issue number9
StatePublished - Dec 1 1975
Externally publishedYes

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Gonadotropin-Releasing Hormone
Proestrus

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Inhibitory activity of four analogs of luteinizing hormone releasing hormone in vivo. / Ferland, L.; Labrie, F.; Coy, D. H.; Coy, E. J.; Schally, Andrew V.

In: Fertility and Sterility, Vol. 26, No. 9, 01.12.1975, p. 889-893.

Research output: Contribution to journalArticle

Ferland, L. ; Labrie, F. ; Coy, D. H. ; Coy, E. J. ; Schally, Andrew V. / Inhibitory activity of four analogs of luteinizing hormone releasing hormone in vivo. In: Fertility and Sterility. 1975 ; Vol. 26, No. 9. pp. 889-893.
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