Inhibitors of apoptosis proteins in injury and disease

George Lotocki, Robert W. Keane

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


The inhibitor of apoptosis (IAP) gene family prevents cell death by binding to and inhibiting caspases. In addition to negatively regulating apoptosis, IAPs bind to signaling intermediates and receptors, and participate in diverse cellular functions. Here, we describe the physiological functions of IAPs and their participation in injury and disease processes.

Original languageEnglish (US)
Pages (from-to)231-240
Number of pages10
JournalIUBMB life
Issue number5
StatePublished - Nov 1 2002


  • Apoptosis
  • Cancer
  • Caspases
  • Excitotoxic injury
  • Inhibitors of apoptosis
  • Neurodegeneration
  • Review
  • Spinal cord injury
  • Transforming growth factor beta signaling
  • Traumatic brain injury
  • Tumor necrosis factor signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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