Inhibitors of apoptosis proteins in injury and disease

George Lotocki, Robert Keane

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The inhibitor of apoptosis (IAP) gene family prevents cell death by binding to and inhibiting caspases. In addition to negatively regulating apoptosis, IAPs bind to signaling intermediates and receptors, and participate in diverse cellular functions. Here, we describe the physiological functions of IAPs and their participation in injury and disease processes.

Original languageEnglish
Pages (from-to)231-240
Number of pages10
JournalIUBMB Life
Volume54
Issue number5
DOIs
StatePublished - Nov 1 2002

Fingerprint

Inhibitor of Apoptosis Proteins
Apoptosis
Wounds and Injuries
Cell death
Caspases
Cell Death
Genes

Keywords

  • Apoptosis
  • Cancer
  • Caspases
  • Excitotoxic injury
  • Inhibitors of apoptosis
  • Neurodegeneration
  • Review
  • Spinal cord injury
  • Transforming growth factor beta signaling
  • Traumatic brain injury
  • Tumor necrosis factor signaling

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Inhibitors of apoptosis proteins in injury and disease. / Lotocki, George; Keane, Robert.

In: IUBMB Life, Vol. 54, No. 5, 01.11.2002, p. 231-240.

Research output: Contribution to journalArticle

Lotocki, George ; Keane, Robert. / Inhibitors of apoptosis proteins in injury and disease. In: IUBMB Life. 2002 ; Vol. 54, No. 5. pp. 231-240.
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