Inhibition of the release of growth hormone in vitro by α-melanocyte stimulating hormone

Andrew V Schally, A. Arimura, A. J. Kastin, T. Uehara, D. H. Coy, E. J. Coy, J. Takahara

Research output: Contribution to journalArticle

9 Scopus citations


A polypeptide isolated from porcine hypothalami was found to inhibit the release of growth hormone (GH) from isolated rat pituitaries. This polypeptide was identified chemically and biologically as α-MSH. Pure natural α-MSH isolated from beef posterior pituitary extracts and synthetic α-MSH also inhibit the release of GH in vitro. In addition, other substances not yet identified, present in porcine hypothalamic extracts, also share this property.

Original languageEnglish
Pages (from-to)1314-1319
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Jun 19 1973
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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