A polypeptide isolated from porcine hypothalami was found to inhibit the release of growth hormone (GH) from isolated rat pituitaries. This polypeptide was identified chemically and biologically as α-MSH. Pure natural α-MSH isolated from beef posterior pituitary extracts and synthetic α-MSH also inhibit the release of GH in vitro. In addition, other substances not yet identified, present in porcine hypothalamic extracts, also share this property.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jun 19 1973|
ASJC Scopus subject areas
- Molecular Biology