Inhibition of the release of growth hormone in vitro by α-melanocyte stimulating hormone

A. V. Schally; A. Arimura; A. J. Kastin; T. Uehara; D. H. Coy; E. J. Coy; J. Takahara

doi:10.1016/0006-291X(73)90644-X

Inhibition of the release of growth hormone in vitro by α-melanocyte stimulating hormone

A. V. Schally, A. Arimura, A. J. Kastin, T. Uehara, D. H. Coy, E. J. Coy, J. Takahara

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

A polypeptide isolated from porcine hypothalami was found to inhibit the release of growth hormone (GH) from isolated rat pituitaries. This polypeptide was identified chemically and biologically as α-MSH. Pure natural α-MSH isolated from beef posterior pituitary extracts and synthetic α-MSH also inhibit the release of GH in vitro. In addition, other substances not yet identified, present in porcine hypothalamic extracts, also share this property.

Original language	English (US)
Pages (from-to)	1314-1319
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/0006-291X(73)90644-X
State	Published - Jun 19 1973
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Schally, A. V., Arimura, A., Kastin, A. J., Uehara, T., Coy, D. H., Coy, E. J., & Takahara, J. (1973). Inhibition of the release of growth hormone in vitro by α-melanocyte stimulating hormone. Biochemical and biophysical research communications, 52(4), 1314-1319. https://doi.org/10.1016/0006-291X(73)90644-X

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AU - Coy, D. H.

AU - Coy, E. J.

AU - Takahara, J.

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