Abstract
A polypeptide isolated from porcine hypothalami was found to inhibit the release of growth hormone (GH) from isolated rat pituitaries. This polypeptide was identified chemically and biologically as α-MSH. Pure natural α-MSH isolated from beef posterior pituitary extracts and synthetic α-MSH also inhibit the release of GH in vitro. In addition, other substances not yet identified, present in porcine hypothalamic extracts, also share this property.
Original language | English (US) |
---|---|
Pages (from-to) | 1314-1319 |
Number of pages | 6 |
Journal | Biochemical and biophysical research communications |
Volume | 52 |
Issue number | 4 |
DOIs | |
State | Published - Jun 19 1973 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology