Inhibition of the pro-inflammatory mediators' production and anti-inflammatory effect of the iridoid scrovalentinoside

Esperanza Bas Infante, M. Carmen Recio, Mohamed Abdallah, Salvador Máñez, Rosa M. Giner, Miguel Cerdá-Nicolás, José Luis Ríos

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have studied scrovalentinoside, an iridoid with anti-inflammatory properties isolated from Scrophularia auriculata ssp. pseudoauriculata, as an anti-inflammatory agent in different experimental models of delayed-type hypersensitivity. We found that scrovalentinoside reduced the edema induced by oxazolone at 0.5 mg/ear and sheep red blood cells at 10 mg/kg. The observed effect occurred during the last phase or inflammatory response; during the earlier phase or induction of the delayed-type hypersensitivity reaction, no significant activity was noted. Thus, scrovalentinoside reduced both the edema and cell infiltration in vivo and reduced lymphocyte proliferation in vitro, affecting the cycle principally during the first 48 h. Whereas cells stimulated with phytohemagglutinin changed from the G0/G1 phase to the S and G2/M phases, when these same cells were treated with scrovalentinoside (100 μM), they remained in the G0/G1 phase. Finally, scrovalentinoside inhibited the production of the pro-inflammatory mediators' TNF-α, IFN-γ, IL-1β, IL-2, IL-4, LTB4, and NO, but had no effect on the production of the anti-inflammatory cytokine IL-10.

Original languageEnglish (US)
Pages (from-to)419-427
Number of pages9
JournalJournal of Ethnopharmacology
Volume110
Issue number3
DOIs
StatePublished - Apr 4 2007
Externally publishedYes

Fingerprint

Anti-Inflammatory Agents
Cell Cycle Resting Phase
Delayed Hypersensitivity
G1 Phase
Scrophularia
Edema
Oxazolone
Leukotriene B4
G2 Phase
Phytohemagglutinins
Interleukin-1
Interleukin-4
Cell Division
Interleukin-10
Interleukin-2
Ear
Sheep
Theoretical Models
Erythrocytes
scrovalentinoside

Keywords

  • Anti-inflammatory activity
  • Cytokines
  • Iridoids
  • Leukotriene B
  • Nitric oxide
  • Nitric oxide synthase
  • Scrophularia auriculata
  • Scrovalentinoside

ASJC Scopus subject areas

  • Pharmacology

Cite this

Inhibition of the pro-inflammatory mediators' production and anti-inflammatory effect of the iridoid scrovalentinoside. / Bas Infante, Esperanza; Recio, M. Carmen; Abdallah, Mohamed; Máñez, Salvador; Giner, Rosa M.; Cerdá-Nicolás, Miguel; Ríos, José Luis.

In: Journal of Ethnopharmacology, Vol. 110, No. 3, 04.04.2007, p. 419-427.

Research output: Contribution to journalArticle

Bas Infante, Esperanza ; Recio, M. Carmen ; Abdallah, Mohamed ; Máñez, Salvador ; Giner, Rosa M. ; Cerdá-Nicolás, Miguel ; Ríos, José Luis. / Inhibition of the pro-inflammatory mediators' production and anti-inflammatory effect of the iridoid scrovalentinoside. In: Journal of Ethnopharmacology. 2007 ; Vol. 110, No. 3. pp. 419-427.
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