Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

Deborah R. Taylor, Stephanie T. Shi, Patrick R. Romano, Glen N Barber, Michael M C Lai

Research output: Contribution to journalArticle

591 Citations (Scopus)

Abstract

Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor elF2α, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalScience
Volume285
Issue number5424
DOIs
StatePublished - Jul 2 1999

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eIF-2 Kinase
Hepacivirus
Interferons
Viral Envelope Proteins
Peptide Initiation Factors
Proteins
Virus Diseases
Antiviral Agents
Phosphotransferases
Phosphorylation
Growth
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. / Taylor, Deborah R.; Shi, Stephanie T.; Romano, Patrick R.; Barber, Glen N; Lai, Michael M C.

In: Science, Vol. 285, No. 5424, 02.07.1999, p. 107-110.

Research output: Contribution to journalArticle

Taylor, Deborah R. ; Shi, Stephanie T. ; Romano, Patrick R. ; Barber, Glen N ; Lai, Michael M C. / Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. In: Science. 1999 ; Vol. 285, No. 5424. pp. 107-110.
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