Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase

W. Glenn L. Kerrick, Phyllis E. Hoar

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


β-adrenergic relaxation of smooth muscle by catecholamines has been associated with elevated levels of cyclic AMP. The question arises whether subsequent activation of cyclic AMP-dependent protein kinase has a role in the regulation of smooth muscle contraction. There is substantial evidence that a Ca2+-activated myosin light chain kinase/phosphatase system regulates smooth muscle contraction, and Adelstein et al. have shown that the catalytic subunit of cyclic ANP-dependent protein kinase plays a part in this regulation, by phosphorylation of the high molecular weight subunit of the light chain kinase, which results in a decrease in the activity of the kinase. Here we have shown for the first time that the catalytic subunit of the protein kinase inhibits Ca2+-activated tension in skinned smooth muscle fibre preparations.

Original languageEnglish (US)
Pages (from-to)253-255
Number of pages3
Issue number5820
StatePublished - 1981

ASJC Scopus subject areas

  • General


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