Inhibition of polyclonal B-cell activation by suppressor monocytes in patients with sarcoidosis

P. Katz, A. S. Fauci

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The present study employed a direct plaque-forming cell (PFC) assay following pokeweed mitogen (PWM) induced polyclonal activation of B lymphocytes in sarcoidosis to evaluate the in vitro humoral immune response in this disease and to delineate the immunoregulation of this response. Sarcoidosis lymphocytes had a suppressed PFC response to polyclonal activation, but were unable to suppress normal B-cell PFC responses in allogeneic co-cultures. Removal of a cell type, which was corticosteroid-resistant, radio-resistant, adherent and a non-T cell, from sarcoidosis mononuclear cell suspensions reversed the suppressed PFC response, indicating the presence of a suppressor monocyte. Thus in vitro suppressor cell activity has now been demonstrated in this disease, which is characterized by multiple immunological aberrancies.

Original languageEnglish (US)
Pages (from-to)554-562
Number of pages9
JournalClinical and Experimental Immunology
Volume32
Issue number3
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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