Inhibition of pancreatic secretion by enkephalin and morphine in dogs

Stanisław J. Konturek, Janina Tasler, Marek Cieszkowski, Jolanta Jaworek, David H. Coy, Andrew V. Schally

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45 Scopus citations

Abstract

The nature and extent of enkephalin- and morphine-induced inhibition of pancreatic bicarbonate and protein secretion were studied in dogs with chronic pancreatic fistulae after administering exogenous secretin or octapeptide of cholecystokinin and stimulants for the endogenous release of these hormones. Enkephalin and morphine competitively inhibited the pancreatic bicarbonate secretion induced either by exogenous secretin or duodenal acidification. This inhibition was partially reversed by naloxone, an opiate antagonist. Opiate substances also profoundly inhibited pancreatic protein response to octapeptide of cholecystokinin and to various stimulants of endogenous cholecystokinin release. We conclude that enkephalin and morphine strongly inhibit the pancreatic responses to exogenous and endogenous stimulants by a mechanism involving separate opiate receptors.

Original languageEnglish (US)
Pages (from-to)851-855
Number of pages5
JournalGastroenterology
Volume74
Issue number5 PART 1
DOIs
StatePublished - May 1978

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Konturek, S. J., Tasler, J., Cieszkowski, M., Jaworek, J., Coy, D. H., & Schally, A. V. (1978). Inhibition of pancreatic secretion by enkephalin and morphine in dogs. Gastroenterology, 74(5 PART 1), 851-855. https://doi.org/10.1016/0016-5085(78)90140-3