Inhibition of pancreatic secretion by enkephalin and morphine in dogs

Stanisław J. Konturek, Janina Tasler, Marek Cieszkowski, Jolanta Jaworek, David H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The nature and extent of enkephalin- and morphine-induced inhibition of pancreatic bicarbonate and protein secretion were studied in dogs with chronic pancreatic fistulae after administering exogenous secretin or octapeptide of cholecystokinin and stimulants for the endogenous release of these hormones. Enkephalin and morphine competitively inhibited the pancreatic bicarbonate secretion induced either by exogenous secretin or duodenal acidification. This inhibition was partially reversed by naloxone, an opiate antagonist. Opiate substances also profoundly inhibited pancreatic protein response to octapeptide of cholecystokinin and to various stimulants of endogenous cholecystokinin release. We conclude that enkephalin and morphine strongly inhibit the pancreatic responses to exogenous and endogenous stimulants by a mechanism involving separate opiate receptors.

Original languageEnglish
Pages (from-to)851-855
Number of pages5
JournalGastroenterology
Volume74
Issue number5 PART 1
StatePublished - Jan 1 1978
Externally publishedYes

Fingerprint

Opiate Alkaloids
Enkephalins
Morphine
Sincalide
Secretin
Dogs
Bicarbonates
Pancreatic Fistula
Cholecystokinin
Opioid Receptors
Naloxone
Proteins
Hormones

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Konturek, S. J., Tasler, J., Cieszkowski, M., Jaworek, J., Coy, D. H., & Schally, A. V. (1978). Inhibition of pancreatic secretion by enkephalin and morphine in dogs. Gastroenterology, 74(5 PART 1), 851-855.

Inhibition of pancreatic secretion by enkephalin and morphine in dogs. / Konturek, Stanisław J.; Tasler, Janina; Cieszkowski, Marek; Jaworek, Jolanta; Coy, David H.; Schally, Andrew V.

In: Gastroenterology, Vol. 74, No. 5 PART 1, 01.01.1978, p. 851-855.

Research output: Contribution to journalArticle

Konturek, SJ, Tasler, J, Cieszkowski, M, Jaworek, J, Coy, DH & Schally, AV 1978, 'Inhibition of pancreatic secretion by enkephalin and morphine in dogs', Gastroenterology, vol. 74, no. 5 PART 1, pp. 851-855.
Konturek SJ, Tasler J, Cieszkowski M, Jaworek J, Coy DH, Schally AV. Inhibition of pancreatic secretion by enkephalin and morphine in dogs. Gastroenterology. 1978 Jan 1;74(5 PART 1):851-855.
Konturek, Stanisław J. ; Tasler, Janina ; Cieszkowski, Marek ; Jaworek, Jolanta ; Coy, David H. ; Schally, Andrew V. / Inhibition of pancreatic secretion by enkephalin and morphine in dogs. In: Gastroenterology. 1978 ; Vol. 74, No. 5 PART 1. pp. 851-855.
@article{80784bbc6673427385b1586e7e6708c2,
title = "Inhibition of pancreatic secretion by enkephalin and morphine in dogs",
abstract = "The nature and extent of enkephalin- and morphine-induced inhibition of pancreatic bicarbonate and protein secretion were studied in dogs with chronic pancreatic fistulae after administering exogenous secretin or octapeptide of cholecystokinin and stimulants for the endogenous release of these hormones. Enkephalin and morphine competitively inhibited the pancreatic bicarbonate secretion induced either by exogenous secretin or duodenal acidification. This inhibition was partially reversed by naloxone, an opiate antagonist. Opiate substances also profoundly inhibited pancreatic protein response to octapeptide of cholecystokinin and to various stimulants of endogenous cholecystokinin release. We conclude that enkephalin and morphine strongly inhibit the pancreatic responses to exogenous and endogenous stimulants by a mechanism involving separate opiate receptors.",
author = "Konturek, {Stanisław J.} and Janina Tasler and Marek Cieszkowski and Jolanta Jaworek and Coy, {David H.} and Schally, {Andrew V}",
year = "1978",
month = "1",
day = "1",
language = "English",
volume = "74",
pages = "851--855",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5 PART 1",

}

TY - JOUR

T1 - Inhibition of pancreatic secretion by enkephalin and morphine in dogs

AU - Konturek, Stanisław J.

AU - Tasler, Janina

AU - Cieszkowski, Marek

AU - Jaworek, Jolanta

AU - Coy, David H.

AU - Schally, Andrew V

PY - 1978/1/1

Y1 - 1978/1/1

N2 - The nature and extent of enkephalin- and morphine-induced inhibition of pancreatic bicarbonate and protein secretion were studied in dogs with chronic pancreatic fistulae after administering exogenous secretin or octapeptide of cholecystokinin and stimulants for the endogenous release of these hormones. Enkephalin and morphine competitively inhibited the pancreatic bicarbonate secretion induced either by exogenous secretin or duodenal acidification. This inhibition was partially reversed by naloxone, an opiate antagonist. Opiate substances also profoundly inhibited pancreatic protein response to octapeptide of cholecystokinin and to various stimulants of endogenous cholecystokinin release. We conclude that enkephalin and morphine strongly inhibit the pancreatic responses to exogenous and endogenous stimulants by a mechanism involving separate opiate receptors.

AB - The nature and extent of enkephalin- and morphine-induced inhibition of pancreatic bicarbonate and protein secretion were studied in dogs with chronic pancreatic fistulae after administering exogenous secretin or octapeptide of cholecystokinin and stimulants for the endogenous release of these hormones. Enkephalin and morphine competitively inhibited the pancreatic bicarbonate secretion induced either by exogenous secretin or duodenal acidification. This inhibition was partially reversed by naloxone, an opiate antagonist. Opiate substances also profoundly inhibited pancreatic protein response to octapeptide of cholecystokinin and to various stimulants of endogenous cholecystokinin release. We conclude that enkephalin and morphine strongly inhibit the pancreatic responses to exogenous and endogenous stimulants by a mechanism involving separate opiate receptors.

UR - http://www.scopus.com/inward/record.url?scp=0018097185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018097185&partnerID=8YFLogxK

M3 - Article

VL - 74

SP - 851

EP - 855

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 5 PART 1

ER -