Inhibition of pancreatic beta cell during glucose clamp in patients with Acanthosis Nigricans

D. Sinagra, C. Randazzo, A. Mistretta, A. Pugliese

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It has long been known that Acanthosis Nigricans is accompanied by insulin resistance. In certain insulin-resistant states, including obesity a more sluggish response to the insulin/insulin inhibition feedback normally present in pancreatic beta cells has been documented. Some have claimed a sort of cell insulin resistance 'parallel' to that of the peripheral tissues. The present study assesses the efficiency of the insulin/insulin feedback in Acanthosis Nigricans patients, measuring the inhibition of the production of C-peptide (the indicator of beta cell secretion) induced by the administration of exogenous insulin during glucose clamping. This was done in order to compare the roles of the peripheral tissues and the beta cells in producing the insulin-resistance typical of Acanthosis Nigricans. The study using the glucose-insulin clamp technique was conducted on 4 Acanthosis Nigricans patients with normal glucose tolerance and 4 healthy controls, the drop in C-peptide levels after the administration of exogenous insulin being assessed in the course of both steady states. The results showed that the Acanthosis Nigricans patients retained a beta cell response to the exogenous insulin though their peripheral tissues presented a reduced sensitivity to insulin as revealed by the glucose-insulin clamp. It therefore seems reasonable to attribute the endocrine metabolic alteration found in Acanthosis Nigricans to a peripheral receptor and/or post receptor alterations rather than central alterations in the beta cells that have yet to be demonstrated. It is concluded that in Acanthosis Nigricans the peripheral insulin resistance is primarily independent phenomenon and not 'parallel' to insulin/insulin feedback.

Original languageEnglish (US)
Pages (from-to)233-235
Number of pages3
JournalMinerva Medica
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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