Abstract
Yersinia pestis and Y. pseudotuberculosis are able to colonize visceral organs and submucosal intestinal epithelial tissue, respectively, without eliciting infiltrating leukocytes to the site of infection. For both pathogens this ability is dependent on the presence of the virulence plasmid and has been proposed to be due to the ability of Yersinia spp. to inhibit infected cells from releasing pro-inflammatory cytokines. We show that YopJ of Y. pseudotuberculosis. which we show is delivered into the cytoplasm of infected cells by a bacterial typeIII secretion system, blocks the degradation of IkB and the subsequent translocation of NF-kB site-binding transcription factors to the nucleus. This activity is dependent on a region of YopJ that resembles a eukaryotic SH2 domain suggesting that YopJ interacts directly with signalling molecules involved in the early host immune response.
| Original language | English |
|---|---|
| Journal | FASEB Journal |
| Volume | 12 |
| Issue number | 5 |
| State | Published - Mar 20 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Inhibition of NF-kB-mediated signalling by the Yersinia - Encoded YopJ protein. / Schesser, Kurt; Spiik, Ann Kristin; Dukuzumuremyi, Jean Marie; Watz, Hans Wolf; Pettersson, Sven.
In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of NF-kB-mediated signalling by the Yersinia - Encoded YopJ protein
AU - Schesser, Kurt
AU - Spiik, Ann Kristin
AU - Dukuzumuremyi, Jean Marie
AU - Watz, Hans Wolf
AU - Pettersson, Sven
PY - 1998/3/20
Y1 - 1998/3/20
N2 - Yersinia pestis and Y. pseudotuberculosis are able to colonize visceral organs and submucosal intestinal epithelial tissue, respectively, without eliciting infiltrating leukocytes to the site of infection. For both pathogens this ability is dependent on the presence of the virulence plasmid and has been proposed to be due to the ability of Yersinia spp. to inhibit infected cells from releasing pro-inflammatory cytokines. We show that YopJ of Y. pseudotuberculosis. which we show is delivered into the cytoplasm of infected cells by a bacterial typeIII secretion system, blocks the degradation of IkB and the subsequent translocation of NF-kB site-binding transcription factors to the nucleus. This activity is dependent on a region of YopJ that resembles a eukaryotic SH2 domain suggesting that YopJ interacts directly with signalling molecules involved in the early host immune response.
AB - Yersinia pestis and Y. pseudotuberculosis are able to colonize visceral organs and submucosal intestinal epithelial tissue, respectively, without eliciting infiltrating leukocytes to the site of infection. For both pathogens this ability is dependent on the presence of the virulence plasmid and has been proposed to be due to the ability of Yersinia spp. to inhibit infected cells from releasing pro-inflammatory cytokines. We show that YopJ of Y. pseudotuberculosis. which we show is delivered into the cytoplasm of infected cells by a bacterial typeIII secretion system, blocks the degradation of IkB and the subsequent translocation of NF-kB site-binding transcription factors to the nucleus. This activity is dependent on a region of YopJ that resembles a eukaryotic SH2 domain suggesting that YopJ interacts directly with signalling molecules involved in the early host immune response.
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UR - http://www.scopus.com/inward/citedby.url?scp=33749371271&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33749371271
VL - 12
JO - FASEB Journal
JF - FASEB Journal
SN - 0892-6638
IS - 5
ER -