Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: Selective review and hypothesis

Andrzej Slominski, Ralf Paus, Martin C. Mihm

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Melanogenesis generates immunosuppressive and mutagenic environment and alters cellular metabolism. Melanin can protect malignant melanocytes against chemo-, radio-, and photodynamic therapy. Therefore, we propose to inhibit melanogenesis as an adjuvant treatment modality during immuno-, radio-, chemo- and photodynamic therapy, and as a measure of reducing the probability of melanoma progression.

Original languageEnglish (US)
Pages (from-to)3709-3715
Number of pages7
JournalAnticancer research
Volume18
Issue number5 B
StatePublished - Sep 1 1998
Externally publishedYes

Keywords

  • Immunosuppression
  • Melanogenesis
  • Progression
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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