Inhibition of Mauthner Cells by Allylglycine

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IN view of the possibility that glycine or glycine-like substances are inhibitory transmitters in the vertebrate central nervous system (CNS)1,2, it is particularly interesting that the derivative, allylglycine (2-amino-4-pentenoic acid), causes convulsions when injected into mice and rats3,4. Last year it was reported that allylglycine in vitro and in vivo reduced the synthesis of the depressant aminoacid, γ-amino-butyric acid (GABA)5, which has itself been suggested as a neural inhibitory substance6,7; it seemed possible therefore that the convulsant properties of allylglycine may be due to a reduction in the concentration of GABA which it produces within the brain5. This communication describes an investigation of allylglycine on the Mauthner cells of goldfish, and in particular any action it may have either directly on these cells or on inhibitory pathways converging on them.

Original languageEnglish (US)
Pages (from-to)373-374
Number of pages2
Issue number5243
StatePublished - Dec 1 1970
Externally publishedYes

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