Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro

F. Labrie; M. Savary; D. H. Coy; E. J. Coy; A. V. Schally

doi:10.1210/endo-98-2-289

Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro

F. Labrie, M. Savary, D. H. Coy, E. J. Coy, A. V. Schally

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12 Scopus citations

Abstract

Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 ^-9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 ^-6M to 3 x 10 ^-5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 ^-5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.

Original language	English (US)
Pages (from-to)	289-294
Number of pages	6
Journal	Endocrinology
Volume	98
Issue number	2
DOIs	https://doi.org/10.1210/endo-98-2-289
State	Published - Feb 1976
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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abstract = "Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.",

author = "F. Labrie and M. Savary and Coy, {D. H.} and Coy, {E. J.} and Schally, {A. V.}",

year = "1976",

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AU - Coy, D. H.

AU - Coy, E. J.

AU - Schally, A. V.

PY - 1976/2

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N2 - Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.

AB - Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.

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Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro

Abstract

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