Abstract
Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 289-294 |
| Number of pages | 6 |
| Journal | Endocrinology |
| Volume | 98 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1976 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology
Fingerprint Dive into the research topics of 'Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro'. Together they form a unique fingerprint.
Cite this
Labrie, F., Savary, M., Coy, D. H., Coy, E. J., & Schally, A. V. (1976). Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro. Endocrinology, 98(2), 289-294. https://doi.org/10.1210/endo-98-2-289