Abstract
Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.
| Original language | English |
|---|---|
| Pages (from-to) | 289-294 |
| Number of pages | 6 |
| Journal | Endocrinology |
| Volume | 98 |
| Issue number | 2 |
| State | Published - Dec 1 1976 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
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Inhibition of luteinizing hormone release by analogs of luteinizing hormone releasing hormone (LHRH) in vitro. / Labrie, F.; Savary, M.; Coy, D. H.; Coy, E. J.; Schally, Andrew V.
In: Endocrinology, Vol. 98, No. 2, 01.12.1976, p. 289-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of luteinizing hormone release by analogs of luteinizing hormone releasing hormone (LHRH) in vitro
AU - Labrie, F.
AU - Savary, M.
AU - Coy, D. H.
AU - Coy, E. J.
AU - Schally, Andrew V
PY - 1976/12/1
Y1 - 1976/12/1
N2 - Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.
AB - Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017236214&partnerID=8YFLogxK
M3 - Article
C2 - 765119
AN - SCOPUS:0017236214
VL - 98
SP - 289
EP - 294
JO - Endocrinology
JF - Endocrinology
SN - 0013-7227
IS - 2
ER -