Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro

F. Labrie; M. Savary; D. H. Coy; E. J. Coy; A. V. Schally

doi:10.1210/endo-98-2-289

Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro

F. Labrie, M. Savary, D. H. Coy, E. J. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 ^-9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 ^-6M to 3 x 10 ^-5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 ^-5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.

Original language	English (US)
Pages (from-to)	289-294
Number of pages	6
Journal	Endocrinology
Volume	98
Issue number	2
DOIs	https://doi.org/10.1210/endo-98-2-289
State	Published - Feb 1976
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

Access to Document

10.1210/endo-98-2-289

Fingerprint Dive into the research topics of 'Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro'. Together they form a unique fingerprint.

Cite this

@article{d4919ce6470049f6b4d80db1460be6f6,

title = "Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro",

abstract = "Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.",

author = "F. Labrie and M. Savary and Coy, {D. H.} and Coy, {E. J.} and Schally, {A. V.}",

year = "1976",

month = feb,

doi = "10.1210/endo-98-2-289",

language = "English (US)",

volume = "98",

pages = "289--294",

journal = "Endocrinology",

issn = "0013-7227",

publisher = "The Endocrine Society",

number = "2",

}

TY - JOUR

T1 - Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro

AU - Labrie, F.

AU - Savary, M.

AU - Coy, D. H.

AU - Coy, E. J.

AU - Schally, A. V.

PY - 1976/2

Y1 - 1976/2

N2 - Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.

AB - Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.

UR - http://www.scopus.com/inward/record.url?scp=0017236214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017236214&partnerID=8YFLogxK

U2 - 10.1210/endo-98-2-289

DO - 10.1210/endo-98-2-289

M3 - Article

C2 - 765119

AN - SCOPUS:0017236214

VL - 98

SP - 289

EP - 294

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 2

ER -

Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Vitro

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this