Abstract
Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.
Original language | English (US) |
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Pages (from-to) | 289-294 |
Number of pages | 6 |
Journal | Endocrinology |
Volume | 98 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology