Inhibition of luteinizing hormone release by analogs of luteinizing hormone releasing hormone (LHRH) in vitro

F. Labrie, M. Savary, D. H. Coy, E. J. Coy, Andrew V Schally

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Sixteen synthetic analogs of LH releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 x 10 -9M LHRH in anterior pituitary cells in monolayer culture. Half maximal inhibition of LHRH induced LH release was obtained with 7 analogs at concentrations which ranged from 3 x 10 -6M to 3 x 10 -5M. None of these seven analogs had significant LH releasing activity at concentrations up to 10 -5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000 fold molar ratio of analog to LHRH.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalEndocrinology
Volume98
Issue number2
StatePublished - Dec 1 1976
Externally publishedYes

Fingerprint

Luteinizing Hormone
Gonadotropin-Releasing Hormone
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Inhibition of luteinizing hormone release by analogs of luteinizing hormone releasing hormone (LHRH) in vitro. / Labrie, F.; Savary, M.; Coy, D. H.; Coy, E. J.; Schally, Andrew V.

In: Endocrinology, Vol. 98, No. 2, 01.12.1976, p. 289-294.

Research output: Contribution to journalArticle

Labrie, F. ; Savary, M. ; Coy, D. H. ; Coy, E. J. ; Schally, Andrew V. / Inhibition of luteinizing hormone release by analogs of luteinizing hormone releasing hormone (LHRH) in vitro. In: Endocrinology. 1976 ; Vol. 98, No. 2. pp. 289-294.
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