Inhibition of human T-cell leukemia virus type I replication in primary human T cells that express antisense RNA

T. Von Ruden, E. Gilboa

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The human T-cell leukemia virus type I is associated with adult T-cell leukemia-lymphoma in humans, a disease which is induced by a malignant transformation of T lymphocytes. Retrovirus vectors carrying human T-cell leukemia virus type I-derived sequences in reversed transcriptional orientation were used to express antisense RNA transcripts in primary human leukocytes. Human T-cell leukemia virus type I replication and virus-mediated immortalization were inhibited in cells harboring antisense constructs. This study suggests that retrovirus-mediated antisense RNA inhibition can be used to protect primary human T-lymphocytes from human T-cell leukemia virus type I-mediated cell transformation.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalJournal of virology
Volume63
Issue number2
StatePublished - Jan 1 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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