Inhibition of hamster tongue carcinogenesis by selenium and retinoic acid

W. Jarrard Goodwin, F. Huijing, G. D. Bordash, N. Altman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The inhibitory effect of selenium, 13-cis-retinoic acid, and their combination was studied in an animal model in which squamous cell carcinoma of the tongue was induced by 0.5% 9,10 dimethyl-1,2 benzanthracene (DMBA). A controlled, blinded experiment was carried out using 60 Syrian hamsters divided into four groups of 15 each. When compared to controls, the mean day of carcinoma onset was delayed 3 weeks for animals given selenium, 6 weeks for animals given retinoic acid, and 5.5 weeks for animals given selenium plus retinoic acid. The differences between each experimental group and the control group are statistically significant. We conclude that both selenium and retinoic acid inhibit the development of DMBA-induced squamous cell carcinoma of the tongue in hamsters. The dose of retinoic acid used produces a stronger inhibitory effect, but is associated with significant toxicity. At the doses used, combined inhibitory effect is no greater than that for retinoic acid alone.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume95
Issue number2 I
StatePublished - Jan 1 1986

Fingerprint

Selenium
Tretinoin
Tongue
Cricetinae
Carcinogenesis
Squamous Cell Carcinoma
Isotretinoin
9,10-Dimethyl-1,2-benzanthracene
Mesocricetus
Animal Models
Carcinoma
Control Groups

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Inhibition of hamster tongue carcinogenesis by selenium and retinoic acid. / Goodwin, W. Jarrard; Huijing, F.; Bordash, G. D.; Altman, N.

In: Annals of Otology, Rhinology and Laryngology, Vol. 95, No. 2 I, 01.01.1986, p. 162-166.

Research output: Contribution to journalArticle

Goodwin, W. Jarrard ; Huijing, F. ; Bordash, G. D. ; Altman, N. / Inhibition of hamster tongue carcinogenesis by selenium and retinoic acid. In: Annals of Otology, Rhinology and Laryngology. 1986 ; Vol. 95, No. 2 I. pp. 162-166.
@article{c1ab8f4c29de4b12a2ca7fbbc35875e7,
title = "Inhibition of hamster tongue carcinogenesis by selenium and retinoic acid",
abstract = "The inhibitory effect of selenium, 13-cis-retinoic acid, and their combination was studied in an animal model in which squamous cell carcinoma of the tongue was induced by 0.5{\%} 9,10 dimethyl-1,2 benzanthracene (DMBA). A controlled, blinded experiment was carried out using 60 Syrian hamsters divided into four groups of 15 each. When compared to controls, the mean day of carcinoma onset was delayed 3 weeks for animals given selenium, 6 weeks for animals given retinoic acid, and 5.5 weeks for animals given selenium plus retinoic acid. The differences between each experimental group and the control group are statistically significant. We conclude that both selenium and retinoic acid inhibit the development of DMBA-induced squamous cell carcinoma of the tongue in hamsters. The dose of retinoic acid used produces a stronger inhibitory effect, but is associated with significant toxicity. At the doses used, combined inhibitory effect is no greater than that for retinoic acid alone.",
author = "Goodwin, {W. Jarrard} and F. Huijing and Bordash, {G. D.} and N. Altman",
year = "1986",
month = "1",
day = "1",
language = "English",
volume = "95",
pages = "162--166",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "2 I",

}

TY - JOUR

T1 - Inhibition of hamster tongue carcinogenesis by selenium and retinoic acid

AU - Goodwin, W. Jarrard

AU - Huijing, F.

AU - Bordash, G. D.

AU - Altman, N.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The inhibitory effect of selenium, 13-cis-retinoic acid, and their combination was studied in an animal model in which squamous cell carcinoma of the tongue was induced by 0.5% 9,10 dimethyl-1,2 benzanthracene (DMBA). A controlled, blinded experiment was carried out using 60 Syrian hamsters divided into four groups of 15 each. When compared to controls, the mean day of carcinoma onset was delayed 3 weeks for animals given selenium, 6 weeks for animals given retinoic acid, and 5.5 weeks for animals given selenium plus retinoic acid. The differences between each experimental group and the control group are statistically significant. We conclude that both selenium and retinoic acid inhibit the development of DMBA-induced squamous cell carcinoma of the tongue in hamsters. The dose of retinoic acid used produces a stronger inhibitory effect, but is associated with significant toxicity. At the doses used, combined inhibitory effect is no greater than that for retinoic acid alone.

AB - The inhibitory effect of selenium, 13-cis-retinoic acid, and their combination was studied in an animal model in which squamous cell carcinoma of the tongue was induced by 0.5% 9,10 dimethyl-1,2 benzanthracene (DMBA). A controlled, blinded experiment was carried out using 60 Syrian hamsters divided into four groups of 15 each. When compared to controls, the mean day of carcinoma onset was delayed 3 weeks for animals given selenium, 6 weeks for animals given retinoic acid, and 5.5 weeks for animals given selenium plus retinoic acid. The differences between each experimental group and the control group are statistically significant. We conclude that both selenium and retinoic acid inhibit the development of DMBA-induced squamous cell carcinoma of the tongue in hamsters. The dose of retinoic acid used produces a stronger inhibitory effect, but is associated with significant toxicity. At the doses used, combined inhibitory effect is no greater than that for retinoic acid alone.

UR - http://www.scopus.com/inward/record.url?scp=0022512263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022512263&partnerID=8YFLogxK

M3 - Article

VL - 95

SP - 162

EP - 166

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 2 I

ER -