Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly

A. L. Charro; J. A. Cabranes; A. Lafuente; C. Diaz-Salgado; M. Cordero; I. Almoguera; A. M. Comaru-Schally; C. A. Meyers; D. H. Coy; A. V. Schally

Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly

A. L. Charro, J. A. Cabranes, A. Lafuente, C. Diaz-Salgado, M. Cordero, I. Almoguera, A. M. Comaru-Schally, C. A. Meyers, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

We have studied growth hormone (GH), insulin (I), glucagon (Gl) and glucose in basal conditions, after somatostatin (SS) (3 μg/ml) and Phe-4-SS (0.75 μg/ml) infusion and IV bolus of the latter in 3 acromegalic patients. In two patients, Phe-4-SS inhibited glucagon and growth hormone secretion in a similar way to SS, without modifying insulin secretion. These effects were short-lived and ceased after the infusion was stopped. From these results it appears that Phe-4-SS is both more potent and more specific than SS with respect to inhibition of GH and glucagon release, but it does not have prolonged biological action. Lack of suppression of GH by SS or Phe-4-SS in the acromegalic patient with post-surgical recurrence of the disease could be due to the existence of receptor abnormalities, and suggests a diversity in the physiopathology of the disease.

Original language	English (US)
Pages (from-to)	432-444
Number of pages	13
Journal	Research communications in chemical pathology and pharmacology
Volume	45
Issue number	3
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

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Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly. / Charro, A. L.; Cabranes, J. A.; Lafuente, A.; Diaz-Salgado, C.; Cordero, M.; Almoguera, I.; Comaru-Schally, A. M.; Meyers, C. A.; Coy, D. H.; Schally, A. V.

In: Research communications in chemical pathology and pharmacology, Vol. 45, No. 3, 1984, p. 432-444.

Research output: Contribution to journal › Article › peer-review

Charro, A. L. ; Cabranes, J. A. ; Lafuente, A. ; Diaz-Salgado, C. ; Cordero, M. ; Almoguera, I. ; Comaru-Schally, A. M. ; Meyers, C. A. ; Coy, D. H. ; Schally, A. V. / Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly. In: Research communications in chemical pathology and pharmacology. 1984 ; Vol. 45, No. 3. pp. 432-444.

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abstract = "We have studied growth hormone (GH), insulin (I), glucagon (Gl) and glucose in basal conditions, after somatostatin (SS) (3 μg/ml) and Phe-4-SS (0.75 μg/ml) infusion and IV bolus of the latter in 3 acromegalic patients. In two patients, Phe-4-SS inhibited glucagon and growth hormone secretion in a similar way to SS, without modifying insulin secretion. These effects were short-lived and ceased after the infusion was stopped. From these results it appears that Phe-4-SS is both more potent and more specific than SS with respect to inhibition of GH and glucagon release, but it does not have prolonged biological action. Lack of suppression of GH by SS or Phe-4-SS in the acromegalic patient with post-surgical recurrence of the disease could be due to the existence of receptor abnormalities, and suggests a diversity in the physiopathology of the disease.",

author = "Charro, {A. L.} and Cabranes, {J. A.} and A. Lafuente and C. Diaz-Salgado and M. Cordero and I. Almoguera and Comaru-Schally, {A. M.} and Meyers, {C. A.} and Coy, {D. H.} and Schally, {A. V.}",

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AU - Cabranes, J. A.

AU - Lafuente, A.

AU - Diaz-Salgado, C.

AU - Cordero, M.

AU - Almoguera, I.

AU - Comaru-Schally, A. M.

AU - Meyers, C. A.

AU - Coy, D. H.

AU - Schally, A. V.

PY - 1984

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N2 - We have studied growth hormone (GH), insulin (I), glucagon (Gl) and glucose in basal conditions, after somatostatin (SS) (3 μg/ml) and Phe-4-SS (0.75 μg/ml) infusion and IV bolus of the latter in 3 acromegalic patients. In two patients, Phe-4-SS inhibited glucagon and growth hormone secretion in a similar way to SS, without modifying insulin secretion. These effects were short-lived and ceased after the infusion was stopped. From these results it appears that Phe-4-SS is both more potent and more specific than SS with respect to inhibition of GH and glucagon release, but it does not have prolonged biological action. Lack of suppression of GH by SS or Phe-4-SS in the acromegalic patient with post-surgical recurrence of the disease could be due to the existence of receptor abnormalities, and suggests a diversity in the physiopathology of the disease.

AB - We have studied growth hormone (GH), insulin (I), glucagon (Gl) and glucose in basal conditions, after somatostatin (SS) (3 μg/ml) and Phe-4-SS (0.75 μg/ml) infusion and IV bolus of the latter in 3 acromegalic patients. In two patients, Phe-4-SS inhibited glucagon and growth hormone secretion in a similar way to SS, without modifying insulin secretion. These effects were short-lived and ceased after the infusion was stopped. From these results it appears that Phe-4-SS is both more potent and more specific than SS with respect to inhibition of GH and glucagon release, but it does not have prolonged biological action. Lack of suppression of GH by SS or Phe-4-SS in the acromegalic patient with post-surgical recurrence of the disease could be due to the existence of receptor abnormalities, and suggests a diversity in the physiopathology of the disease.

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Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly

Abstract

ASJC Scopus subject areas

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