Inhibition of Gonadotropin Release in Chimpanzees by the LH-RH Antagonist (D-Phe2, D-Trp3, D-Phe6)-LH-RH

Robert E. Gosselin, Gene B. Fuller, David H. Coy, Andrew V. Schally, William C. Hobson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

THirty-five mg of the LH-RH antagonist (D-Phe 2, D-Trp 3, D-Phe 6)-LH-RH inhibited the LH response of chimpanzees given 10 μg of LH-RH to 33% of the amount released by control animals. Seven mg of the same analog also attenuated the LH response, but the inhibition was not statistically significant. Neither dose level of the inhibitor significantly altered basal gonadotropin levels. These data indicate that LH-RH antagonists have at least an acute ability to diminish the response to exogenous releasing hormones without acutely affecting basal gonadotropin secretion. They further suggest that a nonhuman primate model may be used to test the efficacy of these compounds as potential contraceptive agents.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume161
Issue number1
DOIs
StatePublished - May 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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