Inhibition of Gonadotropin Release in Chimpanzees by the LH-RH Antagonist (D-Phe2, D-Trp3, D-Phe6)-LH-RH

Robert E. Gosselin; Gene B. Fuller; David H. Coy; Andrew V. Schally; William C. Hobson

doi:10.3181/00379727-161-40480

Inhibition of Gonadotropin Release in Chimpanzees by the LH-RH Antagonist (D-Phe², D-Trp³, D-Phe⁶)-LH-RH

Robert E. Gosselin, Gene B. Fuller, David H. Coy, Andrew V. Schally, William C. Hobson

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

THirty-five mg of the LH-RH antagonist (D-Phe ², D-Trp ³, D-Phe ⁶)-LH-RH inhibited the LH response of chimpanzees given 10 μg of LH-RH to 33% of the amount released by control animals. Seven mg of the same analog also attenuated the LH response, but the inhibition was not statistically significant. Neither dose level of the inhibitor significantly altered basal gonadotropin levels. These data indicate that LH-RH antagonists have at least an acute ability to diminish the response to exogenous releasing hormones without acutely affecting basal gonadotropin secretion. They further suggest that a nonhuman primate model may be used to test the efficacy of these compounds as potential contraceptive agents.

Original language	English (US)
Pages (from-to)	21-24
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	161
Issue number	1
DOIs	https://doi.org/10.3181/00379727-161-40480
State	Published - May 1979
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Inhibition of Gonadotropin Release in Chimpanzees by the LH-RH Antagonist (D-Phe², D-Trp³, D-Phe⁶)-LH-RH. / Gosselin, Robert E.; Fuller, Gene B.; Coy, David H.; Schally, Andrew V.; Hobson, William C.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 161, No. 1, 05.1979, p. 21-24.

Research output: Contribution to journal › Article › peer-review

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abstract = "THirty-five mg of the LH-RH antagonist (D-Phe 2, D-Trp 3, D-Phe 6)-LH-RH inhibited the LH response of chimpanzees given 10 μg of LH-RH to 33% of the amount released by control animals. Seven mg of the same analog also attenuated the LH response, but the inhibition was not statistically significant. Neither dose level of the inhibitor significantly altered basal gonadotropin levels. These data indicate that LH-RH antagonists have at least an acute ability to diminish the response to exogenous releasing hormones without acutely affecting basal gonadotropin secretion. They further suggest that a nonhuman primate model may be used to test the efficacy of these compounds as potential contraceptive agents.",

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AU - Coy, David H.

AU - Schally, Andrew V.

AU - Hobson, William C.

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AB - THirty-five mg of the LH-RH antagonist (D-Phe 2, D-Trp 3, D-Phe 6)-LH-RH inhibited the LH response of chimpanzees given 10 μg of LH-RH to 33% of the amount released by control animals. Seven mg of the same analog also attenuated the LH response, but the inhibition was not statistically significant. Neither dose level of the inhibitor significantly altered basal gonadotropin levels. These data indicate that LH-RH antagonists have at least an acute ability to diminish the response to exogenous releasing hormones without acutely affecting basal gonadotropin secretion. They further suggest that a nonhuman primate model may be used to test the efficacy of these compounds as potential contraceptive agents.

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Inhibition of Gonadotropin Release in Chimpanzees by the LH-RH Antagonist (D-Phe², D-Trp³, D-Phe⁶)-LH-RH

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