INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE

S. R. Bloom, C. H. Mortimer, M. O. Thorner, G. M. Besser, R. Hall, A. Gomez-Pan, V. M. Roy, R. C.G. Russell, D. H. Coy, A. T. Kastin, A. V. Schally

Research output: Contribution to journalArticle

464 Scopus citations

Abstract

The hypothalamic polypeptide growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastrin release in all subjects studied. In normal subjects and in patients with acromegaly during a standard food stimulus a G.H.- R.I.H. infusion completely suppressed gastrin release, and immediately after the infusion was stopped gastrin levels rose sharply to exceed control values. Two patients with pernicious anæmia demonstrated a rapid fall in plasma-gastrin during G.H.-R.I.H. infusion, and in a patient with Zollinger-Ellison syndrome a 20-minute G.H.-R.I.H. infusion greatly lowered plasma-gastrin concentrations and almost totally suppressed gastric-acid production.

Original languageEnglish (US)
Pages (from-to)1106-1109
Number of pages4
JournalThe Lancet
Volume304
Issue number7889
DOIs
StatePublished - Nov 9 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Bloom, S. R., Mortimer, C. H., Thorner, M. O., Besser, G. M., Hall, R., Gomez-Pan, A., Roy, V. M., Russell, R. C. G., Coy, D. H., Kastin, A. T., & Schally, A. V. (1974). INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE. The Lancet, 304(7889), 1106-1109. https://doi.org/10.1016/S0140-6736(74)90869-1