INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE

S. R. Bloom, C. H. Mortimer, M. O. Thorner, G. M. Besser, R. Hall, A. Gomez-Pan, V. M. Roy, R. C G Russell, D. H. Coy, A. T. Kastin, Andrew V Schally

Research output: Contribution to journalArticle

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Abstract

The hypothalamic polypeptide growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastrin release in all subjects studied. In normal subjects and in patients with acromegaly during a standard food stimulus a G.H.- R.I.H. infusion completely suppressed gastrin release, and immediately after the infusion was stopped gastrin levels rose sharply to exceed control values. Two patients with pernicious anæmia demonstrated a rapid fall in plasma-gastrin during G.H.-R.I.H. infusion, and in a patient with Zollinger-Ellison syndrome a 20-minute G.H.-R.I.H. infusion greatly lowered plasma-gastrin concentrations and almost totally suppressed gastric-acid production.

Original languageEnglish
Pages (from-to)1106-1109
Number of pages4
JournalThe Lancet
Volume304
Issue number7889
DOIs
StatePublished - Nov 9 1974
Externally publishedYes

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Gastric Acid
Gastrins
Growth Hormone
Hormones
Hypothalamic Hormones
Zollinger-Ellison Syndrome
Acromegaly
Peptide Hormones
Food

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bloom, S. R., Mortimer, C. H., Thorner, M. O., Besser, G. M., Hall, R., Gomez-Pan, A., ... Schally, A. V. (1974). INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE. The Lancet, 304(7889), 1106-1109. https://doi.org/10.1016/S0140-6736(74)90869-1

INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE. / Bloom, S. R.; Mortimer, C. H.; Thorner, M. O.; Besser, G. M.; Hall, R.; Gomez-Pan, A.; Roy, V. M.; Russell, R. C G; Coy, D. H.; Kastin, A. T.; Schally, Andrew V.

In: The Lancet, Vol. 304, No. 7889, 09.11.1974, p. 1106-1109.

Research output: Contribution to journalArticle

Bloom, SR, Mortimer, CH, Thorner, MO, Besser, GM, Hall, R, Gomez-Pan, A, Roy, VM, Russell, RCG, Coy, DH, Kastin, AT & Schally, AV 1974, 'INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE', The Lancet, vol. 304, no. 7889, pp. 1106-1109. https://doi.org/10.1016/S0140-6736(74)90869-1
Bloom SR, Mortimer CH, Thorner MO, Besser GM, Hall R, Gomez-Pan A et al. INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE. The Lancet. 1974 Nov 9;304(7889):1106-1109. https://doi.org/10.1016/S0140-6736(74)90869-1
Bloom, S. R. ; Mortimer, C. H. ; Thorner, M. O. ; Besser, G. M. ; Hall, R. ; Gomez-Pan, A. ; Roy, V. M. ; Russell, R. C G ; Coy, D. H. ; Kastin, A. T. ; Schally, Andrew V. / INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE. In: The Lancet. 1974 ; Vol. 304, No. 7889. pp. 1106-1109.
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