Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments

Sari Izenwasser, Brian M. Cox

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Chronic administration of cocaine (50 mg/kg/day for 7 days, s.c. via an osmotic minipump) produced tolerance to inhibition of [3H]dopamine uptake by cocaine in rat striatum but did not produce cross-tolerance to inhibition of [3H]dopamine uptake by nicotine. Chronic nicotinic treatment (6 mg/kg/day for 7 days, s.c. via an osmotic minipump), however, produced tolerance to the inhibition of [3H]dopamine uptake by nicotine and cross-tolerance to inhibition of uptake by cocaine in rat striatum. Nicotine did not inhibit uptake of [3H]dopamine in the nucleus accumbens of saline-treated animals. In this tissue, both cocaine and nicotine treatments produced tolerance to cocaine, as in striatum. Unlike the effects on [3H]dopamine uptake, chronic cocaine infusion did not have any effect on the ability of cocaine to inhibit [3H]sorotonin uptake in either brain region.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalBrain Research
Volume573
Issue number1
DOIs
StatePublished - Feb 21 1992

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Keywords

  • Cocaine
  • Dopamine transport
  • Dopamine uptake
  • Nucleus accumbens
  • Serotonin uptake
  • Striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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