Inhibition of basic calcium phosphate crystal-induced mitogenesis by phosphocitrate

Herman S. Cheung, John D. Sallis, Peter G. Mitchell, Janine A. Struve

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Basic calcium phosphate crystals control the traverse of cells from the Go G1 to S-phase of the cell cycle and initiate proliferation by rendering fibroblasts competent to respond to insulin-like growth factors in plasma. Simultaneous addition of phosphocitrate [a powerful inhibitor of hydroxyapatite crystallization] to cells exposed to basic calcium phosphate crystals caused a dose-dependent inhibition of crystal-induced DNA synthesis and c-fos transcription. This inhibition was specific for crystal-induced mitogenesis, since similar concentrations of phosphocitrate had no effects on either PDGF or 10% calf serum-induced thymidine incorporation and c-fos transcription.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalBiochemical and biophysical research communications
Issue number1
StatePublished - Aug 31 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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