Abstract
Basic calcium phosphate crystals control the traverse of cells from the Go G1 to S-phase of the cell cycle and initiate proliferation by rendering fibroblasts competent to respond to insulin-like growth factors in plasma. Simultaneous addition of phosphocitrate [a powerful inhibitor of hydroxyapatite crystallization] to cells exposed to basic calcium phosphate crystals caused a dose-dependent inhibition of crystal-induced DNA synthesis and c-fos transcription. This inhibition was specific for crystal-induced mitogenesis, since similar concentrations of phosphocitrate had no effects on either PDGF or 10% calf serum-induced thymidine incorporation and c-fos transcription.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 20-25 |
| Number of pages | 6 |
| Journal | Biochemical and biophysical research communications |
| Volume | 171 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 31 1990 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Cite this
Cheung, H. S., Sallis, J. D., Mitchell, P. G., & Struve, J. A. (1990). Inhibition of basic calcium phosphate crystal-induced mitogenesis by phosphocitrate. Biochemical and biophysical research communications, 171(1), 20-25. https://doi.org/10.1016/0006-291X(90)91350-2