Protein A, a cell wall constituent of several strains of Staphylococcus aureus, binds strongly to the Fc portion of immunoglobulins. This investigation demonstrated that such bindings can inhibit antibody dependent cellular cytotoxicity (ADCC). The degree to which ADCC was inhibited depended upon the relative concentrations of protein A and anti target cell antiserum. Protein A also inhibited the formation of rosettes between antibody coated sheep red blood cells and lymphoid cells with Fc receptors. The authors, therefore, conclude that protein A inhibits ADCC by preventing the binding of antibody coated target cells to Fc receptors on cytotoxic effector cells.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Immunology|
|State||Published - Jan 1 1977|
ASJC Scopus subject areas
- Immunology and Allergy