Inhibition of antibody dependent cellular cytotoxicity by protein A from Staphylococcus aureus

J. Rosenblatt, P. M. Zeltzer, J. Portaro, R. C. Seeger

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Protein A, a cell wall constituent of several strains of Staphylococcus aureus, binds strongly to the Fc portion of immunoglobulins. This investigation demonstrated that such bindings can inhibit antibody dependent cellular cytotoxicity (ADCC). The degree to which ADCC was inhibited depended upon the relative concentrations of protein A and anti target cell antiserum. Protein A also inhibited the formation of rosettes between antibody coated sheep red blood cells and lymphoid cells with Fc receptors. The authors, therefore, conclude that protein A inhibits ADCC by preventing the binding of antibody coated target cells to Fc receptors on cytotoxic effector cells.

Original languageEnglish (US)
Pages (from-to)981-985
Number of pages5
JournalJournal of Immunology
Volume118
Issue number3
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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