Inhibition of aggregation of a biomimic peptidolipid langmuir monolayer by congo red studied by UV-vis and infrared spectroscopies

Takeshi Hasegawa, Yoshiko Sato, Tetsuo Okada, Masami Shibukawa, Changqing Li, Jhony Orbulescu, Roger Leblanc

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A synthetic peptidolipid consisted of a hydrocarbon chain with a chain length of C18 and a peptide moiety of IIGLM terminated with an amine group, designated as C18IIGLM-NH2, has been employed as a biomimic model compound of amyloid peptide for exploring molecular interaction and orientation with the use of the Langmuir monolayer and Langmuir-Blodgett film techniques. Inspired by a well-known fact that a stain reagent, Congo red (CR), binds well to the amyloid-mimic part (IIGLM), inhibition of molecular aggregation of C18IIGLM-NH2 by interaction with CR was expected, and it has been investigated by use of surface pressure-area isotherm, surface dipole moment-area isotherm, Brewster-angle microscopy, and UV-vis/ infrared spectroscopies. It has been revealed that monomelic CR molecules whose long axis is parallel to the Langmuir monolayer surface are penetrating the C18IIGLM-NH2 Langmuir monolayer, which plays a role of inhibition of molecular aggregation via hydrogen bonding.

Original languageEnglish
Pages (from-to)14227-14232
Number of pages6
JournalJournal of Physical Chemistry B
Volume111
Issue number51
DOIs
StatePublished - Dec 27 2007

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Congo Red
monomolecular films
Ultraviolet spectroscopy
Infrared spectroscopy
Monolayers
Agglomeration
infrared spectroscopy
Amyloid
Peptides
peptides
Isotherms
isotherms
spectroscopy
Brewster angle
Molecular interactions
Molecular orientation
Langmuir Blodgett films
Dipole moment
molecular interactions
Langmuir-Blodgett films

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Inhibition of aggregation of a biomimic peptidolipid langmuir monolayer by congo red studied by UV-vis and infrared spectroscopies. / Hasegawa, Takeshi; Sato, Yoshiko; Okada, Tetsuo; Shibukawa, Masami; Li, Changqing; Orbulescu, Jhony; Leblanc, Roger.

In: Journal of Physical Chemistry B, Vol. 111, No. 51, 27.12.2007, p. 14227-14232.

Research output: Contribution to journalArticle

Hasegawa, Takeshi ; Sato, Yoshiko ; Okada, Tetsuo ; Shibukawa, Masami ; Li, Changqing ; Orbulescu, Jhony ; Leblanc, Roger. / Inhibition of aggregation of a biomimic peptidolipid langmuir monolayer by congo red studied by UV-vis and infrared spectroscopies. In: Journal of Physical Chemistry B. 2007 ; Vol. 111, No. 51. pp. 14227-14232.
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AU - Sato, Yoshiko

AU - Okada, Tetsuo

AU - Shibukawa, Masami

AU - Li, Changqing

AU - Orbulescu, Jhony

AU - Leblanc, Roger

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