Inhibition of adenosine 3′,5′-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone

Pierre Borgeat, Fernand Labrie, Jacques Drouin, Alain Bélanger, Hans Immer, K. Sestanj, V. Nelson, Manfred Gótz, Andrew V. Schally, David H. Coy, Esther J. Coy

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

1 × 10-7M growth hormone-release inhibiting hormone (GH-RIH or somatostatin) leads to a 50% inhibition of adenosine 3′,5′-monophosphate (cyclic AMP) accumulation in anterior pituitary tissue during the first 2 min of incubation. This lowering of cyclic AMP levels is accompanied by inhibition of the release of immunoreactive growth hormone and thyrotropin. GH-RIH has also a marked inhibitory effect on the theophyline- and prostaglandin E2-induced accumulation of adenohypophyseal cyclic AMP.

Original languageEnglish (US)
Pages (from-to)1052-1059
Number of pages8
JournalBiochemical and biophysical research communications
Volume56
Issue number4
DOIs
StatePublished - Feb 27 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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