Inhibition of adenosine 3′,5′-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone

Pierre Borgeat; Fernand Labrie; Jacques Drouin; Alain Bélanger; Hans Immer; K. Sestanj; V. Nelson; Manfred Gótz; Andrew V. Schally; David H. Coy; Esther J. Coy

doi:10.1016/S0006-291X(74)80295-0

Inhibition of adenosine 3′,5′-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone

Pierre Borgeat, Fernand Labrie, Jacques Drouin, Alain Bélanger, Hans Immer, K. Sestanj, V. Nelson, Manfred Gótz, Andrew V. Schally, David H. Coy, Esther J. Coy

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

1 × 10^-7M growth hormone-release inhibiting hormone (GH-RIH or somatostatin) leads to a 50% inhibition of adenosine 3′,5′-monophosphate (cyclic AMP) accumulation in anterior pituitary tissue during the first 2 min of incubation. This lowering of cyclic AMP levels is accompanied by inhibition of the release of immunoreactive growth hormone and thyrotropin. GH-RIH has also a marked inhibitory effect on the theophyline- and prostaglandin E₂-induced accumulation of adenohypophyseal cyclic AMP.

Original language	English (US)
Pages (from-to)	1052-1059
Number of pages	8
Journal	Biochemical and biophysical research communications
Volume	56
Issue number	4
DOIs	https://doi.org/10.1016/S0006-291X(74)80295-0
State	Published - Feb 27 1974
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Borgeat, P., Labrie, F., Drouin, J., Bélanger, A., Immer, H., Sestanj, K., Nelson, V., Gótz, M., Schally, A. V., Coy, D. H., & Coy, E. J. (1974). Inhibition of adenosine 3′,5′-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone. Biochemical and biophysical research communications, 56(4), 1052-1059. https://doi.org/10.1016/S0006-291X(74)80295-0

Inhibition of adenosine 3′,5′-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone. / Borgeat, Pierre; Labrie, Fernand; Drouin, Jacques; Bélanger, Alain; Immer, Hans; Sestanj, K.; Nelson, V.; Gótz, Manfred; Schally, Andrew V.; Coy, David H.; Coy, Esther J.

In: Biochemical and biophysical research communications, Vol. 56, No. 4, 27.02.1974, p. 1052-1059.

Research output: Contribution to journal › Article › peer-review

Borgeat, P, Labrie, F, Drouin, J, Bélanger, A, Immer, H, Sestanj, K, Nelson, V, Gótz, M, Schally, AV, Coy, DH & Coy, EJ 1974, 'Inhibition of adenosine 3′,5′-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone', Biochemical and biophysical research communications, vol. 56, no. 4, pp. 1052-1059. https://doi.org/10.1016/S0006-291X(74)80295-0

Borgeat, Pierre ; Labrie, Fernand ; Drouin, Jacques ; Bélanger, Alain ; Immer, Hans ; Sestanj, K. ; Nelson, V. ; Gótz, Manfred ; Schally, Andrew V. ; Coy, David H. ; Coy, Esther J. / Inhibition of adenosine 3′,5′-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone. In: Biochemical and biophysical research communications. 1974 ; Vol. 56, No. 4. pp. 1052-1059.

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