Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats

E. P. Wei, H. A. Kontos, W. Dalton Dietrich, J. T. Povlishock, E. F. Ellis

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

The authors studied the role of prostaglandins and free radicals in the induction of the functional and morphological pial arteriolar abnormalities produced by concussive brain injury. Anesthetized cats equipped with a cranial window for the observation of the pial microcirculation were subjected to concussive brain injury using a fluid-percussion device following administration of cyclooxygenase inhibitors (indomethacin or AHR-5850) or the vehicle for the solution of these agents (NaCl or Na 2CO 3 solution). Pial arterioles from vehicle-treated animals displayed sustained dilation, reduced responsiveness to the vasoconstrictor effect of arterial hypocapnia, and a high density of endothelial lesions. Animals pretreated with cyclooxygenase inhibitors showed less pronounced vasodilation, normal responsiveness to hypocapnia, and a significantly reduced number of lesions. The vasodilation and reduced responsiveness to the vasoconstrictor effects of hypocapnia after brain injury also were inhibited topical application of free radical scavengers (nitroblue tetrazolium, superoxide dismutase, or mannitol). The vessels from cats pretreated with free radical scavengers also had a lower density of endothelial lesions than controls. The results support the view that the immediate cause of cerebral arteriolar damage in concussive brain injury is the generation of free oxygen radicals associated with increased prostaglandin synthesis.

Original languageEnglish
Pages (from-to)95-103
Number of pages9
JournalCirculation Research
Volume48
Issue number1
StatePublished - Mar 6 1981
Externally publishedYes

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Free Radical Scavengers
Cyclooxygenase Inhibitors
Hypocapnia
Brain Injuries
Cats
Vasoconstrictor Agents
Vasodilation
Free Radicals
Prostaglandins
Percussion
Nitroblue Tetrazolium
Arterioles
Mannitol
Microcirculation
Indomethacin
Superoxide Dismutase
Dilatation
Reactive Oxygen Species
Observation
Equipment and Supplies

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats. / Wei, E. P.; Kontos, H. A.; Dalton Dietrich, W.; Povlishock, J. T.; Ellis, E. F.

In: Circulation Research, Vol. 48, No. 1, 06.03.1981, p. 95-103.

Research output: Contribution to journalArticle

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