Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats

S. Sakamoto, H. Hirai, H. Taga, T. Uchikoshi, T. Sunaga, Y. Endo, H. Kudo, T. Kato, Noriyuki Kasahara, K. Kuwa, R. Okamoto

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It is known that a high incidence of hepatocellular carcinoma in rat liver can be induced by 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB). The administration of 3'MeDAB in combination with 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil (UFT®) delayed the appearance of oval cells and the formation of hyperplastic nodules, which were observed in the liver from 3 and 5 weeks, respectively, after the onset of 3'-MeDAB feeding, and also delayed the transient increase of serum alpha-fetoprotein level, which transiently peaked at 5 weeks, and completely suppressed the transient increase of tissue thymidylate synthetase activity, but not thymidine kinase, which were induced by 3'-MeDAB at 5 weeks, and finally reduced markedly the incidence of hepatocarcinomas. These results indicate that the suppression of de novo synthesis in pyrimidine metabolism prevents hepatocarcinogenesis.

Original languageEnglish (US)
Pages (from-to)561-566
Number of pages6
JournalAnticancer Research
Volume11
Issue number2
StatePublished - 1991
Externally publishedYes

Fingerprint

Methyldimethylaminoazobenzene
Tegafur
Uracil
Thymidylate Synthase
Thymidine Kinase
Liver
Incidence
alpha-Fetoproteins
Hepatocellular Carcinoma
Serum

Keywords

  • α-fetoprotein
  • DNA de novo synthesis
  • DNA synthesizing enzyme
  • hepatocarcinogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats. / Sakamoto, S.; Hirai, H.; Taga, H.; Uchikoshi, T.; Sunaga, T.; Endo, Y.; Kudo, H.; Kato, T.; Kasahara, Noriyuki; Kuwa, K.; Okamoto, R.

In: Anticancer Research, Vol. 11, No. 2, 1991, p. 561-566.

Research output: Contribution to journalArticle

Sakamoto, S, Hirai, H, Taga, H, Uchikoshi, T, Sunaga, T, Endo, Y, Kudo, H, Kato, T, Kasahara, N, Kuwa, K & Okamoto, R 1991, 'Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats', Anticancer Research, vol. 11, no. 2, pp. 561-566.
Sakamoto, S. ; Hirai, H. ; Taga, H. ; Uchikoshi, T. ; Sunaga, T. ; Endo, Y. ; Kudo, H. ; Kato, T. ; Kasahara, Noriyuki ; Kuwa, K. ; Okamoto, R. / Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats. In: Anticancer Research. 1991 ; Vol. 11, No. 2. pp. 561-566.
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AU - Taga, H.

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AU - Sunaga, T.

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AU - Kudo, H.

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AU - Kuwa, K.

AU - Okamoto, R.

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AB - It is known that a high incidence of hepatocellular carcinoma in rat liver can be induced by 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB). The administration of 3'MeDAB in combination with 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil (UFT®) delayed the appearance of oval cells and the formation of hyperplastic nodules, which were observed in the liver from 3 and 5 weeks, respectively, after the onset of 3'-MeDAB feeding, and also delayed the transient increase of serum alpha-fetoprotein level, which transiently peaked at 5 weeks, and completely suppressed the transient increase of tissue thymidylate synthetase activity, but not thymidine kinase, which were induced by 3'-MeDAB at 5 weeks, and finally reduced markedly the incidence of hepatocarcinomas. These results indicate that the suppression of de novo synthesis in pyrimidine metabolism prevents hepatocarcinogenesis.

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