Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats

S. Sakamoto, H. Hirai, H. Taga, T. Uchikoshi, T. Sunaga, Y. Endo, H. Kudo, T. Kato, N. Kasahara, K. Kuwa, R. Okamoto

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

It is known that a high incidence of hepatocellular carcinoma in rat liver can be induced by 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB). The administration of 3'MeDAB in combination with 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil (UFT®) delayed the appearance of oval cells and the formation of hyperplastic nodules, which were observed in the liver from 3 and 5 weeks, respectively, after the onset of 3'-MeDAB feeding, and also delayed the transient increase of serum alpha-fetoprotein level, which transiently peaked at 5 weeks, and completely suppressed the transient increase of tissue thymidylate synthetase activity, but not thymidine kinase, which were induced by 3'-MeDAB at 5 weeks, and finally reduced markedly the incidence of hepatocarcinomas. These results indicate that the suppression of de novo synthesis in pyrimidine metabolism prevents hepatocarcinogenesis.

Original languageEnglish (US)
Pages (from-to)561-566
Number of pages6
JournalAnticancer research
Volume11
Issue number2
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • DNA de novo synthesis
  • DNA synthesizing enzyme
  • hepatocarcinogenesis
  • α-fetoprotein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Sakamoto, S., Hirai, H., Taga, H., Uchikoshi, T., Sunaga, T., Endo, Y., Kudo, H., Kato, T., Kasahara, N., Kuwa, K., & Okamoto, R. (1991). Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats. Anticancer research, 11(2), 561-566.