Inhibin B is lower and anti-Müllerian hormone is similar in serum of men with spinal cord injuries compared to controls

Emad Ibrahim, Teodoro C. Aballa, William E. Roudebush, Charles M Lynne, Nancy Brackett

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Men with spinal cord injury have a unique semen profile characterized by normal sperm concentration but abnormally low sperm motility and viability. The purpose of our study was to determine if new diagnostic information could be obtained for this population by measuring serum concentrations of inhibin B and anti-Müllerian hormone. These hormones, as well as follicle stimulating hormone, luteinizing hormone, and testosterone, were measured in 30 men with spinal cord injury and 15 age-matched control subjects. Serum concentrations of inhibin B and testosterone were significantly lower in the spinal cord injury group compared to the control group. A statistically significant negative relationship was observed between serum concentrations of inhibin B and follicle stimulating hormone in both the spinal cord injury group and the control group, and between inhibin B and luteinizing hormone in the spinal cord injury group only. A significant positive relationship was also observed between inhibin B and sperm concentration in the spinal cord injury group. Although serum concentrations of inhibin B were significantly lower in the spinal cord injury group than in controls, inhibin B and anti-Müllerian hormone serum concentrations did not provide an additional diagnostic tool for male infertility in this population. This is the first study to determine serum concentrations of inhibin B and anti-Müllerian hormone in men with spinal cord injury.

Original languageEnglish (US)
Pages (from-to)72-77
Number of pages6
JournalSystems Biology in Reproductive Medicine
Volume61
Issue number2
DOIs
StatePublished - Apr 1 2015

Keywords

  • Anti-Müllerian hormone
  • Follicle stimulating hormone
  • Inhibin B
  • Luteinizing hormone
  • Sperm
  • Spinal cord injury

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

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