Inherited retinal degeneration: Basic FGF induces phagocytic competence in cultured RPE cells from RCS rats

M. J. McLaren, G. Inana

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

In RCS rats, the retinal pigment epithelium (RPE) is defective in phagocytosis of photoreceptor membranes. We have previously shown reduced expression of basic fibroblast growth factor (bFGF) in the RPE of 7-10-day-old RCS rats. This study using primary RPE cultures from rats of this age demonstrates that the phagocytic defect in the mutant RPE, can be overcome by treatment with bFGF, by a mechanism involving gene transcription and that normal RPE phagocytosis, also requiring transcription, is blocked by a bFGF neutralizing antibody. The combined data point to a role for bFGF in the normal mechanism of RPE phagocytosis and the RCS defect.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalFEBS letters
Volume412
Issue number1
DOIs
StatePublished - Jul 21 1997

Keywords

  • Basic fibroblast growth factor
  • Inherited retinal degeneration
  • Phagocytosis
  • RCS rat
  • RPE cell

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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